Literature DB >> 24973420

Targeting synaptic pathology with a novel affinity mass spectrometry approach.

Ann Brinkmalm1, Gunnar Brinkmalm2, William G Honer3, Julie A Moreno4, Joel Jakobsson2, Giovanna R Mallucci4, Henrik Zetterberg5, Kaj Blennow2, Annika Öhrfelt2.   

Abstract

We report a novel strategy for studying synaptic pathology by concurrently measuring levels of four SNARE complex proteins from individual brain tissue samples. This method combines affinity purification and mass spectrometry and can be applied directly for studies of SNARE complex proteins in multiple species or modified to target other key elements in neuronal function. We use the technique to demonstrate altered levels of presynaptic proteins in Alzheimer disease patients and prion-infected mice.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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Year:  2014        PMID： 24973420      PMCID： PMC4188988          DOI： 10.1074/mcp.M114.040113

Source DB:  PubMed          Journal:  Mol Cell Proteomics        ISSN： 1535-9476            Impact factor:   5.911


  42 in total

Review 1.  The synaptic vesicle cycle.

Authors:  Thomas C Sudhof
Journal:  Annu Rev Neurosci       Date:  2004       Impact factor: 12.449

2.  Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.

Authors:  R D Terry; E Masliah; D P Salmon; N Butters; R DeTeresa; R Hill; L A Hansen; R Katzman
Journal:  Ann Neurol       Date:  1991-10       Impact factor: 10.422

3.  Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.

Authors:  Alexandros Pertsinidis; Konark Mukherjee; Manu Sharma; Zhiping P Pang; Sang Ryul Park; Yunxiang Zhang; Axel T Brunger; Thomas C Südhof; Steven Chu
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-02       Impact factor: 11.205

4.  Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes.

Authors:  Xiaofei Yang; Peng Cao; Thomas C Südhof
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-02       Impact factor: 11.205

5.  SNAP receptors implicated in vesicle targeting and fusion.

Authors:  T Söllner; S W Whiteheart; M Brunner; H Erdjument-Bromage; S Geromanos; P Tempst; J E Rothman
Journal:  Nature       Date:  1993-03-25       Impact factor: 49.962

6.  Heterogeneous expression of SNAP-25 in rat and human brain.

Authors:  Rita Garbelli; Francesca Inverardi; Valentina Medici; Alida Amadeo; Claudia Verderio; Michela Matteoli; Carolina Frassoni
Journal:  J Comp Neurol       Date:  2008-01-20       Impact factor: 3.215

7.  Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25.

Authors:  I C Bark; M C Wilson
Journal:  Gene       Date:  1994-02-25       Impact factor: 3.688

8.  An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid.

Authors:  Gunnar Brinkmalm; Erik Portelius; Annika Öhrfelt; Niklas Mattsson; Rita Persson; Mikael K Gustavsson; Charles H Vite; Johan Gobom; Jan-Eric Månsson; Jonas Nilsson; Adnan Halim; Göran Larson; Ulla Rüetschi; Henrik Zetterberg; Kaj Blennow; Ann Brinkmalm
Journal:  J Mass Spectrom       Date:  2012-05       Impact factor: 1.982

9.  Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration.

Authors:  G R Mallucci; S Ratté; E A Asante; J Linehan; I Gowland; J G R Jefferys; J Collinge
Journal:  EMBO J       Date:  2002-02-01       Impact factor: 11.598

10.  The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations.

Authors:  G A Oyler; G A Higgins; R A Hart; E Battenberg; M Billingsley; F E Bloom; M C Wilson
Journal:  J Cell Biol       Date:  1989-12       Impact factor: 10.539
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  11 in total

1.  Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain.

Authors:  Alfredo Ramos-Miguel; Kristina Gicas; Jehan Alamri; Clare L Beasley; Andrew J Dwork; J John Mann; Gorazd Rosoklija; Fang Cai; Weihong Song; Alasdair M Barr; William G Honer
Journal:  Neuroscience       Date:  2018-12-21       Impact factor: 3.590

2.  The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1.

Authors:  Alfredo Ramos-Miguel; Vilte Barakauskas; Jehan Alamri; Masatoshi Miyauchi; Alasdair M Barr; Clare L Beasley; Gorazd Rosoklija; J John Mann; Andrew J Dwork; Annie Moradian; Gregg B Morin; William G Honer
Journal:  Neuroscience       Date:  2019-01-02       Impact factor: 3.590

Review 3.  Electrochemistry at the Synapse.

Authors:  Mimi Shin; Ying Wang; Jason R Borgus; B Jill Venton
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2019-02-01       Impact factor: 10.745

4.  Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability.

Authors:  Martijn C de Wilde; Cassia R Overk; John W Sijben; Eliezer Masliah
Journal:  Alzheimers Dement       Date:  2016-01-14       Impact factor: 21.566

Review 5.  The past and the future of Alzheimer's disease CSF biomarkers-a journey toward validated biochemical tests covering the whole spectrum of molecular events.

Authors:  Kaj Blennow; Henrik Zetterberg
Journal:  Front Neurosci       Date:  2015-09-29       Impact factor: 4.677

6.  Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry.

Authors:  Simon Sjödin; Annika Öhrfelt; Gunnar Brinkmalm; Henrik Zetterberg; Kaj Blennow; Ann Brinkmalm
Journal:  Clin Proteomics       Date:  2016-02-25       Impact factor: 3.988

7.  Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders.

Authors:  Annalisa Alfieri; Oksana Sorokina; Annie Adrait; Costanza Angelini; Isabella Russo; Alessandro Morellato; Michela Matteoli; Elisabetta Menna; Elisabetta Boeri Erba; Colin McLean; J Douglas Armstrong; Ugo Ala; Joseph D Buxbaum; Alfredo Brusco; Yohann Couté; Silvia De Rubeis; Emilia Turco; Paola Defilippi
Journal:  Front Mol Neurosci       Date:  2017-06-30       Impact factor: 5.639

8.  CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects.

Authors:  Chengai Xu; Carl M Sellgren; Helena Fatouros-Bergman; Fredrik Piehl; Kaj Blennow; Henrik Zetterberg; Ann Brinkmalm; Alexander Frizell Santillo; Sofia Lundgren; Simon Cervenka; Göran Engberg; Sophie Erhardt
Journal:  IBRO Rep       Date:  2020-04-13

Review 9.  The synaptic pathology of cognitive life
.

Authors:  William G Honer; Alfredo Ramos-Miguel; Jehan Alamri; Ken Sawada; Alasdair M Barr; Julie A Schneider; David A Bennett
Journal:  Dialogues Clin Neurosci       Date:  2019-09       Impact factor: 5.986

10.  Proteomic comparison of different synaptosome preparation procedures.

Authors:  Péter Gulyássy; Gina Puska; Balázs A Györffy; Katalin Todorov-Völgyi; Gábor Juhász; László Drahos; Katalin Adrienna Kékesi
Journal:  Amino Acids       Date:  2020-11-19       Impact factor: 3.520
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