Jenny S W Lee1, T W Auyeung2, Jason Leung3, Dicken Chan3, Timothy Kwok4, Jean Woo5, Y K Wing6. 1. Division of Geriatrics, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; The S. H. Ho Centre for Gerontology and Geriatrics, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Medicine and Geriatrics, Shatin Hospital, Hong Kong SAR, China. Electronic address: jennylee@cuhk.edu.hk. 2. The S. H. Ho Centre for Gerontology and Geriatrics, The Chinese University of Hong Kong, Hong Kong SAR, China. 3. The Jockey Club Centre for Osteoporosis Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. 4. Division of Geriatrics, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. 5. Division of Geriatrics, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; The S. H. Ho Centre for Gerontology and Geriatrics, The Chinese University of Hong Kong, Hong Kong SAR, China. 6. Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Abstract
OBJECTIVES: Although general adult population studies show a U-shaped association between sleep duration and mortality, prolonged rather than short sleep duration was more consistently associated with higher mortality in older populations. Failing health or frailty is a possible mechanism. Thus, we examined the relationship among sleep duration, frailty status, and mortality in an elderly cohort. METHODS: A total of 3427 community-living adults 65 years or older were examined for general health, mood, subjective sleep measures (insomnia, napping, sleep apnea, nighttime sleep duration, sleep medications), frailty, and 5-year mortality. RESULTS: After 5 years, 12.9% of men and 4.5% of women had died. Mean nighttime sleep duration was 7.3 hours. Proportion of participants who slept 10 or more hours increased with increasing frailty. Age-adjusted hazard ratio (HR) for 5-year mortality of long nighttime sleep (≥ 10 hours) was 2.10 (95% confidence interval [CI] 1.33-3.33) in men, and 2.70 (95% CI 0.98-7.46) in women. The HR in men was attenuated (HR 1.75; 95% CI 1.09-2.81) after adjustment for frailty and other covariates, whereas that of women strengthened (HR 2.88; 95% CI 1.01-8.18). Mortality increased sharply with nighttime sleep of 10 hours or more. Nighttime sleep of 10 or more hours (HR 1.75, men; HR 2.88, women) and frailty (HR 2.43, men; HR 2.08, P = .08 in women) were independently associated with 5-year mortality after full adjustment for covariates. CONCLUSION: Frailty and long nighttime sleep duration of 10 or more hours were independently associated with 5-year mortality in older adults.
OBJECTIVES: Although general adult population studies show a U-shaped association between sleep duration and mortality, prolonged rather than short sleep duration was more consistently associated with higher mortality in older populations. Failing health or frailty is a possible mechanism. Thus, we examined the relationship among sleep duration, frailty status, and mortality in an elderly cohort. METHODS: A total of 3427 community-living adults 65 years or older were examined for general health, mood, subjective sleep measures (insomnia, napping, sleep apnea, nighttime sleep duration, sleep medications), frailty, and 5-year mortality. RESULTS: After 5 years, 12.9% of men and 4.5% of women had died. Mean nighttime sleep duration was 7.3 hours. Proportion of participants who slept 10 or more hours increased with increasing frailty. Age-adjusted hazard ratio (HR) for 5-year mortality of long nighttime sleep (≥ 10 hours) was 2.10 (95% confidence interval [CI] 1.33-3.33) in men, and 2.70 (95% CI 0.98-7.46) in women. The HR in men was attenuated (HR 1.75; 95% CI 1.09-2.81) after adjustment for frailty and other covariates, whereas that of women strengthened (HR 2.88; 95% CI 1.01-8.18). Mortality increased sharply with nighttime sleep of 10 hours or more. Nighttime sleep of 10 or more hours (HR 1.75, men; HR 2.88, women) and frailty (HR 2.43, men; HR 2.08, P = .08 in women) were independently associated with 5-year mortality after full adjustment for covariates. CONCLUSION: Frailty and long nighttime sleep duration of 10 or more hours were independently associated with 5-year mortality in older adults.
Authors: S Nakakubo; H Makizako; T Doi; K Tsutsumimoto; R Hotta; S Lee; S Lee; S Bae; K Makino; T Suzuki; H Shimada Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Jennifer L Guida; Alfonso J Alfini; Lisa Gallicchio; Adam P Spira; Neil E Caporaso; Paige A Green Journal: Sleep Date: 2021-07-09 Impact factor: 5.849
Authors: Andressa Alves da Silva; Renato Gorga Bandeira de Mello; Camila Wohlgemuth Schaan; Flávio D Fuchs; Susan Redline; Sandra C Fuchs Journal: BMJ Open Date: 2016-02-17 Impact factor: 2.692