Robin Haring1, Sebastian E Baumeister2, Wolfgang Lieb3, Bettina von Sarnowski4, Henry Völzke5, Stephan B Felix6, Matthias Nauck7, Henri Wallaschofski7. 1. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Germany. Electronic address: robin.haring@uni-greifswald.de. 2. Institute for Community Medicine, University Medicine Greifswald, Germany. 3. Institute for Community Medicine, University Medicine Greifswald, Germany; Institute of Epidemiology, Christian Albrechts University Kiel, Germany. 4. Department of Neurology, University Medicine Greifswald, Germany. 5. DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Germany. 6. DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Germany; Department of Cardiology, University Medicine Greifswald, Germany. 7. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Germany.
Abstract
BACKGROUND: Elevated glycated hemoglobin (HbA1c) is associated with increased risk of cardiovascular disease (CVD) and mortality but little is known about potential mechanisms underlying the reported associations. METHODS: We used data from 1798 non-diabetic participants from the population-based cohort Study of Health in Pomerania (SHIP) to investigate cross-sectional and longitudinal associations of HbA1c with subclinical atherosclerosis (common carotid artery intima-media thickness [CCA-IMT]), cardiac structure (left ventricular mass [LVM]), and cardiac function (fractional shortening). RESULTS: Cross-sectional analyses revealed a positive association between HbA1c and mean CCA-IMT with a 0.02 mm (95% confidence interval: 0.01-0.04) increase in CCA-IMT per 1% increase in HbA1c, and a similar positive trend across HbA1c quartiles (overall p-value <0.01). We also observed a graded association between HbA1c and high CCA-IMT (>75th percentile) with an odds ratio of 1.42 (95% CI: 1.11-1.81) per 1% increase in HbA1c. Longitudinal analyses showed no consistent associations of baseline HbA1c with mean follow-up CCA-IMT. There were no consistent associations of HbA1c with cardiac remodeling in cross-sectional and longitudinal analyses, respectively. CONCLUSIONS: The association between HbA1c and CCA-IMT in non-diabetic adults may be a crucial link between high-normal HbA1c levels and an increased risk of CVD and mortality.
BACKGROUND: Elevated glycated hemoglobin (HbA1c) is associated with increased risk of cardiovascular disease (CVD) and mortality but little is known about potential mechanisms underlying the reported associations. METHODS: We used data from 1798 non-diabeticparticipants from the population-based cohort Study of Health in Pomerania (SHIP) to investigate cross-sectional and longitudinal associations of HbA1c with subclinical atherosclerosis (common carotid artery intima-media thickness [CCA-IMT]), cardiac structure (left ventricular mass [LVM]), and cardiac function (fractional shortening). RESULTS: Cross-sectional analyses revealed a positive association between HbA1c and mean CCA-IMT with a 0.02 mm (95% confidence interval: 0.01-0.04) increase in CCA-IMT per 1% increase in HbA1c, and a similar positive trend across HbA1c quartiles (overall p-value <0.01). We also observed a graded association between HbA1c and high CCA-IMT (>75th percentile) with an odds ratio of 1.42 (95% CI: 1.11-1.81) per 1% increase in HbA1c. Longitudinal analyses showed no consistent associations of baseline HbA1c with mean follow-up CCA-IMT. There were no consistent associations of HbA1c with cardiac remodeling in cross-sectional and longitudinal analyses, respectively. CONCLUSIONS: The association between HbA1c and CCA-IMT in non-diabetic adults may be a crucial link between high-normal HbA1c levels and an increased risk of CVD and mortality.
Authors: Manuel A Gomez-Marcos; Leticia Gomez-Sanchez; Maria C Patino-Alonso; Jose I Recio-Rodriguez; Natividad Garcia Regalado; Rafel Ramos; Ruth Marti; Cristina Agudo-Conde; Emiliano Rodriguez-Sanchez; Jose A Maderuelo-Fernandez; Luis Garcia-Ortiz Journal: BMC Cardiovasc Disord Date: 2016-10-28 Impact factor: 2.298
Authors: Laura H van Dongen; Marieke T Blom; Abdenasser Bardai; Paulien C M Homma; Joline W J Beulens; Amber A van der Heijden; Petra Elders; Hanno L Tan Journal: Europace Date: 2020-03-01 Impact factor: 5.214