Literature DB >> 24972008

1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

Sergio Valente1, Daniela Trisciuoglio, Teresa De Luca, Angela Nebbioso, Donatella Labella, Alessia Lenoci, Chiara Bigogno, Giulio Dondio, Marco Miceli, Gerald Brosch, Donatella Del Bufalo, Lucia Altucci, Antonello Mai.   

Abstract

We describe 1,3,4-oxadiazole-containing hydroxamates (2) and 2-aminoanilides (3) as histone deacetylase inhibitors. Among them, 2t, 2x, and 3i were the most potent and selective against HDAC1. In U937 leukemia cells, 2t was more potent than SAHA in inducing apoptosis, and 3i displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, 3i showed higher antiproliferative effects than SAHA.

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Year:  2014        PMID： 24972008     DOI： 10.1021/jm500303u

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  19 in total

1.  Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.

Authors:  Samuel Bouchet; Camille Linot; Dusan Ruzic; Danica Agbaba; Benoit Fouchaq; Joëlle Roche; Katarina Nikolic; Christophe Blanquart; Philippe Bertrand
Journal:  ACS Med Chem Lett       Date:  2019-05-09       Impact factor: 4.345

2.  Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors.

Authors:  Idris Raji; Kabir Ahluwalia; Adegboyega K Oyelere
Journal:  Bioorg Med Chem Lett       Date:  2017-01-17       Impact factor: 2.823

3.  Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells.

Authors:  Asami Hichino; Miki Okamoto; Saeko Taga; Risa Akizuki; Satoshi Endo; Toshiyuki Matsunaga; Akira Ikari
Journal:  J Biol Chem       Date:  2017-01-05       Impact factor: 5.157

Review 4.  DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application.

Authors:  Chunhong Hu; Xiaohan Liu; Yue Zeng; Junqi Liu; Fang Wu
Journal:  Clin Epigenetics       Date:  2021-08-27       Impact factor: 6.551

Review 5.  Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents.

Authors:  Harshita Sachdeva; Sarita Khaturia; Mohammad Saquib; Narsingh Khatik; Abhinav Raj Khandelwal; Ravina Meena; Khushboo Sharma
Journal:  Appl Biochem Biotechnol       Date:  2022-07-28       Impact factor: 3.094

6.  Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni.

Authors:  Elisabetta Di Bello; Beatrice Noce; Rossella Fioravanti; Clemens Zwergel; Sergio Valente; Dante Rotili; Giulia Fianco; Daniela Trisciuoglio; Marina M Mourão; Policarpo Sales; Suzanne Lamotte; Eric Prina; Gerald F Späth; Cécile Häberli; Jennifer Keiser; Antonello Mai
Journal:  ACS Infect Dis       Date:  2022-06-22       Impact factor: 5.578

7.  Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis.

Authors:  Yen-Chia Huang; Fang-I Huang; Samir Mehndiratta; Ssu-Chia Lai; Jing-Ping Liou; Chia-Ron Yang
Journal:  Oncotarget       Date:  2015-07-30

8.  Quantitative and qualitative analysis of the novel antitumor 1,3,4-oxadiazole derivative (GLB) and its metabolites using HPLC-UV and UPLC-QTOF-MS.

Authors:  Pu Li; Xin Wang; Jian Li; Zhi-Yun Meng; Shu-Chun Li; Zhong-Jun Li; Ying-Yuan Lu; Hong Ren; Ya-Qing Lou; Chuang Lu; Gui-Fang Dou; Guo-Liang Zhang
Journal:  Sci Rep       Date:  2015-07-07       Impact factor: 4.379

9.  Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells.

Authors:  Marta Di Martile; Marianna Desideri; Teresa De Luca; Chiara Gabellini; Simonetta Buglioni; Adriana Eramo; Giovanni Sette; Michele Milella; Dante Rotili; Antonello Mai; Simone Carradori; Daniela Secci; Ruggero De Maria; Donatella Del Bufalo; Daniela Trisciuoglio
Journal:  Oncotarget       Date:  2016-03-08

10.  Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives.

Authors:  Camelia Elena Stecoza; George Mihai Nitulescu; Constantin Draghici; Miron Teodor Caproiu; Octavian Tudorel Olaru; Marinela Bostan; Mirela Mihaila
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-06
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