Beatriz Valera1, Edouard Suhas, Emilie Counil, Paul Poirier, Eric Dewailly. 1. a Axe Santé des Populations et Environnement, Centre de Recherche du CHUQ , Quebec , CANADA (B.V., E.D.); Institut Louis Malardé , Papeete , POLYNÉSIE FRANÇAISE (E.S.); École des Hautes Études en Santé Publique, Département épidémiologie et biostatistiques , Paris , FRANCE (E.C.); IRIS , UMR 8156-997, Bobigny , FRANCE (E.C.); Quebec Heart and Lung Institute, Laval Hospital Research Centre (P.P.), Faculty of Pharmacy (P.P.), Department of Social and Preventive Medicine (E.D.), Laval University , Quebec , CANADA.
Abstract
OBJECTIVE: To analyze the associations between marine n-3 polyunsaturated fatty acids (PUFAs) and blood pressure (BP), resting heart rate (HR), and heart rate variability (HRV) in a population highly exposed to methylmercury through the diet. METHODS: Concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in erythrocytes membranes were measured in 180 French Polynesian adults (≥18 years) residing in Tubuai, which is a community with a traditional lifestyle, or Papeete, which has a modern lifestyle. HRV was measured using a 2-hour ambulatory electrocardiogram (Holter). Resting HR and BP were measured using standardized protocols and pulse pressure (PP) was calculated as systolic BP - diastolic BP. The associations between n-3 PUFAs and the dependent variables were studied using simple and multiple linear regressions. RESULTS: Increasing DHA concentration was associated with lower resting HR (β = -2.57, p = 0.005) and diastolic BP (β = -1.96, p = 0.05) and higher HRV in multivariable models. Specifically, DHA was associated with high frequency (HF; β = 0.19, p = 0.02) and the square root of the mean squared differences of successive R-R intervals (difference between two consecutive R waves; rMSSD; β = 0.08, p = 0.03), which are specific indices of the parasympathetic activity of the autonomic nervous system. CONCLUSION: DHA was associated with lower BP and resting HR and higher HRV among French Polynesians who are also exposed to high methylmercury levels.
OBJECTIVE: To analyze the associations between marine n-3 polyunsaturated fatty acids (PUFAs) and blood pressure (BP), resting heart rate (HR), and heart rate variability (HRV) in a population highly exposed to methylmercury through the diet. METHODS: Concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in erythrocytes membranes were measured in 180 French Polynesian adults (≥18 years) residing in Tubuai, which is a community with a traditional lifestyle, or Papeete, which has a modern lifestyle. HRV was measured using a 2-hour ambulatory electrocardiogram (Holter). Resting HR and BP were measured using standardized protocols and pulse pressure (PP) was calculated as systolic BP - diastolic BP. The associations between n-3 PUFAs and the dependent variables were studied using simple and multiple linear regressions. RESULTS: Increasing DHA concentration was associated with lower resting HR (β = -2.57, p = 0.005) and diastolic BP (β = -1.96, p = 0.05) and higher HRV in multivariable models. Specifically, DHA was associated with high frequency (HF; β = 0.19, p = 0.02) and the square root of the mean squared differences of successive R-R intervals (difference between two consecutive R waves; rMSSD; β = 0.08, p = 0.03), which are specific indices of the parasympathetic activity of the autonomic nervous system. CONCLUSION:DHA was associated with lower BP and resting HR and higher HRV among French Polynesians who are also exposed to high methylmercury levels.
Authors: Mark L Wells; Philippe Potin; James S Craigie; John A Raven; Sabeeha S Merchant; Katherine E Helliwell; Alison G Smith; Mary Ellen Camire; Susan H Brawley Journal: J Appl Phycol Date: 2016-11-21 Impact factor: 3.215