Stephen P Glasser1, Mary K Wojczynski2, A I Oberman1, Edmond K Kabagambe2, Michael Y Tsai3, Jose M Ordovas4, Robert J Straka5, Donna K Arnett2. 1. Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, AL 35294-1150, USA. 2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL 35294-1150, USA. 3. Department of Laboratory Medicine and Pathology, University of Minnesota, MN 55455-0213, USA. 4. Lipid Metabolism Laboratory, Tufts University, MA 02155, USA. 5. Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, MN 55455-0213, USA.
Abstract
CONTEXT: The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied. OBJECTIVE: To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemic participants. METHODS: Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree. RESULTS: Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/-0.7 to 4 +/-0.4 and 78 / -4 to 36 / -3 nmol/L both P < .0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 = / - 37 to 1088 = / - 36 nmol/L, P < .0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters. CONCLUSION: Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.
CONTEXT: The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied. OBJECTIVE: To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemicparticipants. METHODS:Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree. RESULTS: Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/-0.7 to 4 +/-0.4 and 78 / -4 to 36 / -3 nmol/L both P < .0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 = / - 37 to 1088 = / - 36 nmol/L, P < .0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters. CONCLUSION:Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.
Authors: Dolores Corella; Donna K Arnett; Michael Y Tsai; Edmond K Kabagambe; James M Peacock; James E Hixson; Robert J Straka; Michael Province; Chao-Qiang Lai; Laurence D Parnell; Ingrid Borecki; Jose M Ordovas Journal: Clin Chem Date: 2007-04-19 Impact factor: 8.327
Authors: Xin Geng; Marguerite R Irvin; Bertha Hidalgo; Stella Aslibekyan; Vinodh Srinivasasainagendra; Ping An; Alexis C Frazier-Wood; Hemant K Tiwari; Tushar Dave; Kathleen Ryan; Jose M Ordovas; Robert J Straka; Mary F Feitosa; Paul N Hopkins; Ingrid Borecki; Michael A Province; Braxton D Mitchell; Donna K Arnett; Degui Zhi Journal: J Lipid Res Date: 2018-02-20 Impact factor: 5.922