Literature DB >> 2497107

Differential responses to growth factors by normal human mesothelial cultures from individual donors.

J F Lechner1, M A LaVeck, B I Gerwin, E A Matis.   

Abstract

A significant interindividual variation in the growth rates is found in normal cultured human mesothelial (NHM) cells derived from different donors. This variation is observed when the mesothelial cells are incubated in medium containing serum and when the potencies of several separate growth factors are measured by using defined media. Depending on the donor, gamma-interferon and interleukin-2 can be toxic, have no effect, or stimulate the growth rate of NHM cells. Cultured NHM cells can be induced to multiply by growth factors that are released by activated macrophages. Thus, interindividual variation in NHM cell growth control could play a role in the pathogenesis of mesothelioma for a person exposed to asbestos.

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Year:  1989        PMID： 2497107     DOI： 10.1002/jcp.1041390211

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  9 in total

1.  A cobblestone cell isolated from the human omentum: the mesothelial cell; isolation, identification, and growth characteristics.

Authors:  A Pronk; P Leguit; A A Hoynck van Papendrecht; E Hagelen; T J van Vroonhoven; H A Verbrugh
Journal:  In Vitro Cell Dev Biol       Date:  1993-02

2.  Growth of normal human ovarian surface epithelial cells in reduced-serum and serum-free media.

Authors:  W M Elliott; N Auersperg
Journal:  In Vitro Cell Dev Biol       Date:  1993-01

3.  Phenotypic and functional characteristics of porcine peritoneal mesothelial cells.

Authors:  J Ohan; M A Gilbert; J P Brouland; J P Rougier; G Trugnan; M Wassef; G Leseche; L Drouet
Journal:  In Vitro Cell Dev Biol Anim       Date:  1999 Nov-Dec       Impact factor: 2.416

4.  Stimulation of mesothelial cell proliferation by exudate macrophages enhances serosal wound healing in a murine model.

Authors:  Steven E Mutsaers; Darrel Whitaker; John M Papadimitriou
Journal:  Am J Pathol       Date:  2002-02       Impact factor: 4.307

Review 5.  Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.

Authors:  J F Lechner; J Tesfaigzi; B I Gerwin
Journal:  Environ Health Perspect       Date:  1997-09       Impact factor: 9.031

6.  Growth factor modulation of rat pleural mesothelial cell mitogenesis and collagen synthesis. Effects of epidermal growth factor and platelet-derived factor.

Authors:  M W Owens; S A Milligan
Journal:  Inflammation       Date:  1994-02       Impact factor: 4.092

7.  High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines.

Authors:  S Ungar; A Van de Meeren; L Tammilehto; K Linnainmaa; K Mattson; B I Gerwin
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

8.  Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells.

Authors:  N Jonjić; G Peri; S Bernasconi; F L Sciacca; F Colotta; P Pelicci; L Lanfrancone; A Mantovani
Journal:  J Exp Med       Date:  1992-10-01       Impact factor: 14.307

9.  Autocrine stimulation of a human lung mesothelioma cell line is mediated through the transforming growth factor alpha/epidermal growth factor receptor mitogenic pathway.

Authors:  I A Mórocz; D Schmitter; B Lauber; R A Stahel
Journal:  Br J Cancer       Date:  1994-11       Impact factor: 7.640
  9 in total

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