Literature DB >> 2497020

Potent contractile effect of endothelin in isolated guinea-pig airways.

C A Maggi1, R Patacchini, S Giuliani, A Meli.   

Abstract

Endothelin produced a concentration-dependent (1 nM-0.3 microM) contraction of isolated guinea-pig airways (trachea and main bronchi). The response was unaffected by tetrodotoxin (1 microM) and slightly depressed by indomethacin (5 microM) but promptly abolished by isoprenaline (1 microM) or EDTA (3 mM). In the bronchi, the response to endothelin was enhanced by removal (rubbing) of the epithelium. The response of the trachea or bronchi to endothelin (0.3 microM) was unaffected by NiCl2 (0.1 mM) or omega conotoxin (0.1 microM) but was partially inhibited by nifedipine (1 microM).

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Year:  1989        PMID： 2497020     DOI： 10.1016/0014-2999(89)90670-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  22 in total

1.  Endothelin-1-induced [3H]-inositol phosphate accumulation in rat trachea.

Authors:  P J Henry; P J Rigby; G J Self; J M Preuss; R G Goldie
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

2.  The mechanism of action of endothelin in human lung.

Authors:  K O McKay; J L Black; C L Armour
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

3.  The effect of thiorphan and epithelium removal on contractions and tachykinin release produced by activation of capsaicin-sensitive afferents in the guinea-pig isolated bronchus.

Authors:  C A Maggi; R Patacchini; F Perretti; S Meini; S Manzini; P Santicioli; E Del Bianco; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

4.  Contractile activity of three endothelins (ET-1, ET-2 and ET-3) on the human isolated bronchus.

Authors:  C Advenier; B Sarria; E Naline; L Puybasset; V Lagente
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739

5.  Mechanism of endothelin-induced contraction in guinea-pig trachea: comparison with rat aorta.

Authors:  D W Hay
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

6.  Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.

Authors:  D W Hay; W C Hubbard; B J Undem
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

7.  Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma.

Authors:  N Lebel; P D'Orléans-Juste; A Fournier; P Sirois
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

8.  Pharmacological modulation of endothelin-induced contraction of guinea-pig isolated airways and thromboxane release.

Authors:  J G Filep; B Battistini; P Sirois
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

9.  Endothelin-induced contraction and mediator release in human bronchus.

Authors:  D W Hay; W C Hubbard; B J Undem
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

10.  Contractile activity of big endothelin-1 on the human isolated bronchus.

Authors:  C Advenier; V Lagente; Y Zhang; E Naline
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739
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