OBJECTIVE: Beclin-1 has recently been observed as an essential marker of autophagy in several cancers. However, the prognostic role of Beclin-1 in colorectal neoplasia remains controversial. Our study aimed to evaluate the potential association between Beclin-1 expression and the outcome of colorectal cancer patients. MATERIALS AND METHODS: All related studies were systematically searched in Pubmed, Embase, Springer and Chinese National Knowledge Infrastructure databases (CNKI), and then a meta-analysis was performed to determine the association of Beclin-1 expression with clinical outcomes. Finally, a total of 6 articles were included in our analysis. RESULTS: Our data showed that high Beclin-1 expression in patients with CRC was associated with poor prognosis in terms of tumor distant metastasis (OR=2.090, 95%CI=1.061-4.119, p=0.033) and overall survival (RR=1.422, 95%CI=1.032-1.959, p=0.031). However, we did not found any correlation between Beclin-1 over-expression and tumor differentiation (OR=1.711, 95%CI=0.920-3.183, p=0.090). In addition, there was no evidence of publication bias as suggested by Egger's tests for tumor distant metastasis (p=1.000), differentiation (p=1.000) and OS (p=0.308). CONCLUSIONS: Our present meta-analysis indicated that elevated Beclin-1 expression iss associated with tumor metastasis and a poor prognosis in patients with CRC. Beclin-1 might serve as an efficient prognostic indicator in CRC, and could be a new molecular target in CRC therapy.
OBJECTIVE:Beclin-1 has recently been observed as an essential marker of autophagy in several cancers. However, the prognostic role of Beclin-1 in colorectal neoplasia remains controversial. Our study aimed to evaluate the potential association between Beclin-1 expression and the outcome of colorectal cancerpatients. MATERIALS AND METHODS: All related studies were systematically searched in Pubmed, Embase, Springer and Chinese National Knowledge Infrastructure databases (CNKI), and then a meta-analysis was performed to determine the association of Beclin-1 expression with clinical outcomes. Finally, a total of 6 articles were included in our analysis. RESULTS: Our data showed that high Beclin-1 expression in patients with CRC was associated with poor prognosis in terms of tumor distant metastasis (OR=2.090, 95%CI=1.061-4.119, p=0.033) and overall survival (RR=1.422, 95%CI=1.032-1.959, p=0.031). However, we did not found any correlation between Beclin-1 over-expression and tumor differentiation (OR=1.711, 95%CI=0.920-3.183, p=0.090). In addition, there was no evidence of publication bias as suggested by Egger's tests for tumor distant metastasis (p=1.000), differentiation (p=1.000) and OS (p=0.308). CONCLUSIONS: Our present meta-analysis indicated that elevated Beclin-1 expression iss associated with tumor metastasis and a poor prognosis in patients with CRC. Beclin-1 might serve as an efficient prognostic indicator in CRC, and could be a new molecular target in CRC therapy.
Authors: Aziz Zaanan; Jae Myung Park; David Tougeron; Shengbing Huang; Tsung-Teh Wu; Nathan R Foster; Frank A Sinicrope Journal: Int J Cancer Date: 2015-03-09 Impact factor: 7.396
Authors: Florin Burada; Elena Raluca Nicoli; Marius Eugen Ciurea; Daniel Constantin Uscatu; Mihai Ioana; Dan Ionut Gheonea Journal: World J Gastrointest Oncol Date: 2015-11-15
Authors: Koichiro Haruki; Keisuke Kosumi; Tsuyoshi Hamada; Tyler S Twombly; Juha P Väyrynen; Sun A Kim; Yohei Masugi; Zhi Rong Qian; Kosuke Mima; Yoshifumi Baba; Annacarolina da Silva; Jennifer Borowsky; Kota Arima; Kenji Fujiyoshi; Mai Chan Lau; Peilong Li; Chunguang Guo; Yang Chen; Mingyang Song; Jonathan A Nowak; Reiko Nishihara; Katsuhiko Yanaga; Xuehong Zhang; Kana Wu; Susan Bullman; Wendy S Garrett; Curtis Huttenhower; Jeffrey A Meyerhardt; Marios Giannakis; Andrew T Chan; Charles S Fuchs; Shuji Ogino Journal: J Pathol Date: 2020-02-03 Impact factor: 7.996