David Bourchier1, Philip John Weston. 1. NICU, Waikato Hospital, Pembroke St, Hamilton, New Zealand, david.bourchier@waikatodhb.health.nz.
Abstract
UNLABELLED: Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit of 10.6 mmol/l and had resolved in 90 % of infants by day 11. Dopamine usage was the only independent predictor of the acidosis. Its use was associated with a greater degree of acidosis. CONCLUSION: Extremely preterm infants experience a self-limiting normal anion gap metabolic acidosis in the first 2 weeks of life which is consistent with renal tubular immaturity.
UNLABELLED: Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit of 10.6 mmol/l and had resolved in 90 % of infants by day 11. Dopamine usage was the only independent predictor of the acidosis. Its use was associated with a greater degree of acidosis. CONCLUSION: Extremely preterm infants experience a self-limiting normal anion gap metabolic acidosis in the first 2 weeks of life which is consistent with renal tubular immaturity.
Authors: M Meneghelli; A Pasinato; S Salvadori; P Gaio; M Fantinato; V Vanzo; F De Terlizzi; G Verlato Journal: J Perinatol Date: 2016-01-14 Impact factor: 2.521
Authors: Molly E McCarthy; Scott P Oltman; Rebecca J Baer; Kelli K Ryckman; Elizabeth E Rogers; Martina A Steurer-Muller; John S Witte; Laura L Jelliffe-Pawlowski Journal: Clin Transl Sci Date: 2018-10-28 Impact factor: 4.689