| Literature DB >> 2496891 |
M B Jørgensen1, J Deckert, D C Wright, D R Gehlert.
Abstract
The relative levels of c-fos mRNA in individual neurons of the hippocampal formation of rats is dramatically increased following 20 min of cerebral ischemia induced by 4-vessel occlusion. After 24 h of recirculation, a number of scattered neurons in the dentate hilus became hybridization positive. This effect appeared to peak between 24 and 48 h. A few neurons in the pyramidal cell layer of CA1 expressed c-fos as early as 24 h, but the most intense labeling in this region was seen at 72 h of recirculation. These results correlate well with the known distribution of delayed ischemic necrosis in the brain.Entities:
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Year: 1989 PMID： 2496891 DOI： 10.1016/0006-8993(89)90388-0
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252