Literature DB >> 24967620

Systemic regulation of mammalian ageing and longevity by brain sirtuins.

Akiko Satoh1, Shin-ichiro Imai1.   

Abstract

Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.

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Year:  2014        PMID： 24967620      PMCID： PMC4521907          DOI： 10.1038/ncomms5211

Source DB:  PubMed          Journal:  Nat Commun        ISSN： 2041-1723            Impact factor:   14.919


  149 in total

1.  Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.

Authors:  Shinji Kume; Takashi Uzu; Kihachiro Horiike; Masami Chin-Kanasaki; Keiji Isshiki; Shin-Ichi Araki; Toshiro Sugimoto; Masakazu Haneda; Atsunori Kashiwagi; Daisuke Koya
Journal:  J Clin Invest       Date:  2010-03-24       Impact factor: 14.808

2.  The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms.

Authors:  Joshua J Gooley; Ashley Schomer; Clifford B Saper
Journal:  Nat Neurosci       Date:  2006-02-19       Impact factor: 24.884

3.  Hypothalamic Sirt1 regulates food intake in a rodent model system.

Authors:  Işin Cakir; Mario Perello; Omar Lansari; Norma J Messier; Charles A Vaslet; Eduardo A Nillni
Journal:  PLoS One       Date:  2009-12-15       Impact factor: 3.240

4.  Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.

Authors:  Masaya Tanno; Jun Sakamoto; Tetsuji Miura; Kazuaki Shimamoto; Yoshiyuki Horio
Journal:  J Biol Chem       Date:  2006-12-30       Impact factor: 5.157

5.  Age-related changes in sleep in inbred mice are genotype dependent.

Authors:  Sibah Hasan; Yves Dauvilliers; Valérie Mongrain; Paul Franken; Mehdi Tafti
Journal:  Neurobiol Aging       Date:  2010-07-09       Impact factor: 4.673

6.  Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Authors:  Randy Strong; Richard A Miller; Clinton M Astle; Joseph A Baur; Rafael de Cabo; Elizabeth Fernandez; Wen Guo; Martin Javors; James L Kirkland; James F Nelson; David A Sinclair; Bruce Teter; David Williams; Nurulain Zaveri; Nancy L Nadon; David E Harrison
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-26       Impact factor: 6.053

7.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors:  M Kaeberlein; M McVey; L Guarente
Journal:  Genes Dev       Date:  1999-10-01       Impact factor: 11.361

8.  Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.

Authors:  Bing Gong; Yong Pan; Prashant Vempati; Wei Zhao; Lindsay Knable; Lap Ho; Jun Wang; Magdalena Sastre; Kenjiro Ono; Anthony A Sauve; Giulio M Pasinetti
Journal:  Neurobiol Aging       Date:  2013-01-09       Impact factor: 4.673

9.  PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

Authors:  Péter Bai; Carles Cantó; Hugues Oudart; Attila Brunyánszki; Yana Cen; Charles Thomas; Hiroyasu Yamamoto; Aline Huber; Borbála Kiss; Riekelt H Houtkooper; Kristina Schoonjans; Valérie Schreiber; Anthony A Sauve; Josiane Menissier-de Murcia; Johan Auwerx
Journal:  Cell Metab       Date:  2011-04-06       Impact factor: 27.287

10.  Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet.

Authors:  Byeong Tak Jeon; Eun Ae Jeong; Hyun Joo Shin; Younghyurk Lee; Dong Hoon Lee; Hyun Joon Kim; Sang Soo Kang; Gyeong Jae Cho; Wan Sung Choi; Gu Seob Roh
Journal:  Diabetes       Date:  2012-02-23       Impact factor: 9.461
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  24 in total

1.  SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.

Authors:  Ban Wang; Youjun Zhang; Wei Cao; Xunbing Wei; James Chen; Weihai Ying
Journal:  Neurochem Res       Date:  2016-06-27       Impact factor: 3.996

Review 2.  The brain, sirtuins, and ageing.

Authors:  Akiko Satoh; Shin-Ichiro Imai; Leonard Guarente
Journal:  Nat Rev Neurosci       Date:  2017-05-18       Impact factor: 34.870

3.  SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice.

Authors:  Myeong Jin Yoon; Mitsukuni Yoshida; Sean Johnson; Akiko Takikawa; Isao Usui; Kazuyuki Tobe; Takashi Nakagawa; Jun Yoshino; Shin-ichiro Imai
Journal:  Cell Metab       Date:  2015-04-23       Impact factor: 27.287

Review 4.  Nutrigenomics at the Interface of Aging, Lifespan, and Cancer Prevention.

Authors:  Gabriela Riscuta
Journal:  J Nutr       Date:  2016-08-24       Impact factor: 4.798

5.  Effects of long-term resveratrol treatment in hypothalamic astrocyte cultures from aged rats.

Authors:  Vanessa Sovrani; Larissa Daniele Bobermin; Camila Leite Santos; Morgana Brondani; Carlos-Alberto Gonçalves; Guilhian Leipnitz; André Quincozes-Santos
Journal:  Mol Cell Biochem       Date:  2022-10-22       Impact factor: 3.842

6.  NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.

Authors:  Jonathan B Lin; Shunsuke Kubota; Norimitsu Ban; Mitsukuni Yoshida; Andrea Santeford; Abdoulaye Sene; Rei Nakamura; Nicole Zapata; Miyuki Kubota; Kazuo Tsubota; Jun Yoshino; Shin-Ichiro Imai; Rajendra S Apte
Journal:  Cell Rep       Date:  2016-09-27       Impact factor: 9.423

7.  Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.

Authors:  D F Silva; A R Esteves; C R Oliveira; S M Cardoso
Journal:  Mol Neurobiol       Date:  2016-06-17       Impact factor: 5.590

8.  Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity.

Authors:  Akiko Satoh; Cynthia S Brace; Nick Rensing; Shin-Ichiro Imai
Journal:  Aging Cell       Date:  2014-12-25       Impact factor: 9.304

9.  Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation.

Authors:  Xuben Hou; David Rooklin; Hao Fang; Yingkai Zhang
Journal:  Sci Rep       Date:  2016-11-30       Impact factor: 4.379

10.  Predicting all-cause mortality from basic physiology in the Framingham Heart Study.

Authors:  William B Zhang; Zachary Pincus
Journal:  Aging Cell       Date:  2015-10-08       Impact factor: 9.304
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