Emel Saglar1, Banu Bozkurt2, Murat Irkec3. 1. Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara 06800, Turkey. 2. Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya 42131, Turkey. 3. Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.
Abstract
AIM: To investigate the association between apolipoprotein E (APOE) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG). METHODS: Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test. RESULTS: Although the frequency of APOE -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype. CONCLUSION: APOE -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.
AIM: To investigate the association between apolipoprotein E (APOE) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG). METHODS:Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test. RESULTS: Although the frequency of APOE -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucomapatients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucomapatients with GT genotype. CONCLUSION:APOE -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.
Entities:
Keywords:
apolipoprotein E; primary open angle glaucoma; promoter; single nucleotide polymorphism
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