Jing Ji1, Xing Wei1, Yueling Wang1. 1. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Medical School, Xi'an Jiaotong University Medical School 277 West Yanta Road, Xi'an 710061, China.
Abstract
BACKGROUND: Both the expression of embryonic stem cells (ESCs) markers (Sox2, Oct4) and the Wnt signal pathway (β-catenin) are crucial for progression of various human malignancies. The purpose of this study was to investigate the clinicopathologic significance of Sox2, Oct4 and β-catenin in cervical squamous cell carcinoma (CSCC) and to study their correlation with the occurrence and prognosis. METHODS: Sox2, Oct4 and β-catenin were assessed using immunohistochemistry in normal cervix tissues (n=28) and invasive cervical squamous cell carcinoma (n=43). Associations of Sox2, Oct4 and β-catenin levels with clinicopathological characteristics and with overall survival were studied using uni- and multivariate analysis. RESULTS: The expression levels of Sox2, Oct4 and β-catenin were highly increased in CSCC compared with the normal cervix tissues. The ESCs markers expression (Sox2 and Oct4) correlated significantly with β-catenin expression. High expression of Sox2, but not that of Oct4 or β-catenin, was correlated with poorer differentiation (P<0.05). Furthermore, Sox2 expression was significantly correlated with patients' status of survival in advanced CSCC (P<0.05), whereas there was no significant finding in Oct4 or β-catenin expression. CONCLUSIONS: These findings provide evidence that both ESCs biomarkers (Sox2, Oct4) and Wnt signal pathway (β-catenin) are activated in CSCC. Sox2 can be regarded as a novel predictor of poor prognosis for CSCC patients.
BACKGROUND: Both the expression of embryonic stem cells (ESCs) markers (Sox2, Oct4) and the Wnt signal pathway (β-catenin) are crucial for progression of various humanmalignancies. The purpose of this study was to investigate the clinicopathologic significance of Sox2, Oct4 and β-catenin in cervical squamous cell carcinoma (CSCC) and to study their correlation with the occurrence and prognosis. METHODS:Sox2, Oct4 and β-catenin were assessed using immunohistochemistry in normal cervix tissues (n=28) and invasive cervical squamous cell carcinoma (n=43). Associations of Sox2, Oct4 and β-catenin levels with clinicopathological characteristics and with overall survival were studied using uni- and multivariate analysis. RESULTS: The expression levels of Sox2, Oct4 and β-catenin were highly increased in CSCC compared with the normal cervix tissues. The ESCs markers expression (Sox2 and Oct4) correlated significantly with β-catenin expression. High expression of Sox2, but not that of Oct4 or β-catenin, was correlated with poorer differentiation (P<0.05). Furthermore, Sox2 expression was significantly correlated with patients' status of survival in advanced CSCC (P<0.05), whereas there was no significant finding in Oct4 or β-catenin expression. CONCLUSIONS: These findings provide evidence that both ESCs biomarkers (Sox2, Oct4) and Wnt signal pathway (β-catenin) are activated in CSCC. Sox2 can be regarded as a novel predictor of poor prognosis for CSCC patients.
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