| Literature DB >> 24966934 |
Vanessa Villegas-Ruíz1, Mauricio Salcedo1, Alejandro Zentella-Dehesa2, Edén V Montes de Oca3, Edgar Román-Basaure4, Alejandra Mantilla-Morales5, Víctor M Dávila-Borja6, Sergio Juárez-Méndez6.
Abstract
Cervical cancer is the second malignancy in Mexico, little is known about the prognostic factors associated with this disease. Several cellular components are important in their transformation and progression. Alternative mRNA splice is an important mechanism for generating protein diversity, nevertheless, in cancer unknown mRNA diversity is expressed. Hyaluronan-mediated motility receptor (HMMR, RHAMM, CD168) is a family member of proteins, hyaluronan acid dependent, and has been associated with different malignant processes such as: angiogenesis, cell invasiveness, proliferation, metastasis and poor outcome in some tumors. In the present study we identified expression of HMMR in cervical cancer by means of RT-PCR and sequencing. Our results indicate co-expression of two HMMR variants in all samples, and one case expressed three alternative HMMR splice transcripts. These results showed the heterogeneity of mRNA transcripts of HMMR that could express in cancer and the expression of HMMR could be marker of malignancy in CC.Entities:
Keywords: Cervical cancer; HMMR; alternative splicing; expression
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Year: 2014 PMID： 24966934 PMCID： PMC4069874
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625