| Literature DB >> 2496591 |
J G Elferink1, M Deierkauf, J A Kramps, H K Koerten.
Abstract
Chrysotile asbestos induces extensive enzyme release from polymorphonuclear leukocytes (PMNs). The release of the cytoplasmic enzyme lactate dehydrogenase implies membrane damage and cytotoxicity. In the presence of extracellular Ca2+ asbestos exerts an activating effect, evident from the release of granule-associated enzymes by exocytosis. Both the cytotoxic and activating effect of asbestos may contribute to asbestos-induced tissue damage.Entities:
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Year: 1989 PMID： 2496591 DOI： 10.1007/bf02126614
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299