Literature DB >> 24965476

Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress.

Mayuri Sharma1, Donald M Coen2.   

Abstract

Human cytomegalovirus (HCMV) kinase UL97 is required for efficient nuclear lamina disruption during nuclear egress. However, cellular protein kinase C (PKC) has been implicated in this process in other systems. Comparing the effects of UL97 and cellular kinase inhibitors on HCMV nuclear egress confirms a role for UL97 in lamina disruption and nuclear egress. A pan-PKC inhibitor did not affect lamina disruption but did reduce the number of cytoplasmic capsids more than the number of nuclear capsids.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24965476      PMCID： PMC4178862          DOI： 10.1128/JVI.01391-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

Review 1.  Herpesvirus assembly and egress.

Authors:  Thomas C Mettenleiter
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

2.  Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina.

Authors:  Walter Muranyi; Jürgen Haas; Markus Wagner; Georg Krohne; Ulrich H Koszinowski
Journal:  Science       Date:  2002-08-02       Impact factor: 47.728

3.  Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

Authors:  L Meijer; A Borgne; O Mulner; J P Chong; J J Blow; N Inagaki; M Inagaki; J G Delcros; J P Moulinoux
Journal:  Eur J Biochem       Date:  1997-01-15

4.  Human cytomegalovirus UL50 and UL53 recruit viral protein kinase UL97, not protein kinase C, for disruption of nuclear lamina and nuclear egress in infected cells.

Authors:  Mayuri Sharma; Jeremy P Kamil; Margaret Coughlin; Natalia I Reim; Donald M Coen
Journal:  J Virol       Date:  2013-10-23       Impact factor: 5.103

5.  Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics.

Authors:  B A Hocevar; D J Burns; A P Fields
Journal:  J Biol Chem       Date:  1993-04-05       Impact factor: 5.157

6.  Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production.

Authors:  Veronica Sanchez; Anita K McElroy; Judy Yen; Sama Tamrakar; Charles L Clark; Rachel A Schwartz; Deborah H Spector
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

7.  The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

Authors:  D Toullec; P Pianetti; H Coste; P Bellevergue; T Grand-Perret; M Ajakane; V Baudet; P Boissin; E Boursier; F Loriolle
Journal:  J Biol Chem       Date:  1991-08-25       Impact factor: 5.157

8.  In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.

Authors:  Stephanie L Williams; Caroll B Hartline; Nicole L Kushner; Emma A Harden; Deborah J Bidanset; John C Drach; Leroy B Townsend; Mark R Underwood; Karen K Biron; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

9.  Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus.

Authors:  Veronica Sanchez; Anita K McElroy; Deborah H Spector
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

10.  The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.

Authors:  Paula M Krosky; Moon-Chang Baek; Donald M Coen
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103
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  12 in total

1.  Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions.

Authors:  Sascha A Walzer; Claudia Egerer-Sieber; Heinrich Sticht; Madhumati Sevvana; Katharina Hohl; Jens Milbradt; Yves A Muller; Manfred Marschall
Journal:  J Biol Chem       Date:  2015-10-02       Impact factor: 5.157

2.  The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50.

Authors:  Myoung Kyu Lee; Seokhwan Hyeon; Jin-Hyun Ahn
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

3.  Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.

Authors:  Ming F Lye; Mayuri Sharma; Kamel El Omari; David J Filman; Jonathan P Schuermann; James M Hogle; Donald M Coen
Journal:  EMBO J       Date:  2015-10-28       Impact factor: 11.598

4.  A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress.

Authors:  Adrian R Wilkie; Mayuri Sharma; Jean M Pesola; Maria Ericsson; Rosio Fernandez; Donald M Coen
Journal:  J Virol       Date:  2018-02-26       Impact factor: 5.103

5.  Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex.

Authors:  Mayuri Sharma; Brian J Bender; Jeremy P Kamil; Ming F Lye; Jean M Pesola; Natalia I Reim; James M Hogle; Donald M Coen
Journal:  J Virol       Date:  2014-10-22       Impact factor: 5.103

6.  Human cytomegalovirus pUL97 kinase induces global changes in the infected cell phosphoproteome.

Authors:  Adam Oberstein; David H Perlman; Thomas Shenk; Laura J Terry
Journal:  Proteomics       Date:  2015-05-12       Impact factor: 3.984

Review 7.  'Come together'-The Regulatory Interaction of Herpesviral Nuclear Egress Proteins Comprises Both Essential and Accessory Functions.

Authors:  Sigrun Häge; Manfred Marschall
Journal:  Cells       Date:  2022-06-04       Impact factor: 7.666

8.  Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins.

Authors:  Mayuri Sharma; Jeremy P Kamil; Donald M Coen
Journal:  Methods Enzymol       Date:  2015-09-11       Impact factor: 1.600

9.  Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.

Authors:  Myoung Kyu Lee; Ye Ji Kim; Young-Eui Kim; Tae-Hee Han; Jens Milbradt; Manfred Marschall; Jin-Hyun Ahn
Journal:  J Virol       Date:  2018-07-17       Impact factor: 5.103

10.  Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97.

Authors:  Jens Milbradt; Eric Sonntag; Sabrina Wagner; Hanife Strojan; Christina Wangen; Tihana Lenac Rovis; Berislav Lisnic; Stipan Jonjic; Heinrich Sticht; William J Britt; Ursula Schlötzer-Schrehardt; Manfred Marschall
Journal:  Viruses       Date:  2018-01-13       Impact factor: 5.048
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