Literature DB >> 24965354

The effect of LfcinB9 on human ovarian cancer cell SK-OV-3 is mediated by inducing apoptosis.

Minjia Sheng1, Yanjie Zhao, Aichen Zhang, Liyan Wang, Guizhen Zhang.   

Abstract

LfcinB9 is a peptide derived from lactoferricin B. In the present study, the effect and relative mechanism of LfcinB9 on human ovarian cancer cell line (SK-OV-3) in vitro and in vivo was investigated. The data obtained indicated that LfcinB9 exhibited low hemolysis activity and significantly inhibited the proliferation of SK-OV-3 cells in vitro. In addition, the apoptosis of SK-OV-3 cells was induced through up-regulating the production of reactive oxygen species and activating caspase-3, caspase-9 on both transcription and translation level. Finally, LfcinB9 significantly prevented the tumor growth in the SK-OV-3-bearing mice model. These results indicated that LfcinB9 could be a potential agent for the treatment of ovarian cancer.
Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.

Entities:  

Keywords:  Caspase-3/9; LfcinB9; ROS; apoptosis; ovarian cancer

Mesh：

Substances：

Year:  2014        PMID： 24965354     DOI： 10.1002/psc.2670

Source DB:  PubMed          Journal:  J Pept Sci        ISSN： 1075-2617            Impact factor:   1.905


  6 in total

1.  The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells.

Authors:  Tao Xu; Tongxing Cui; Lipan Peng; Shuai Kong; Jianqiang Zou; Xingsong Tian
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2.  Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells.

Authors:  Lixiang Meng; Geliang Xu; Jiansheng Li; Wenbin Liu; Weidong Jia; Jinliang Ma; Decheng Wei
Journal:  Oncol Lett       Date:  2016-11-22       Impact factor: 2.967

3.  The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways.

Authors:  Juan Zhou; Mengjing Zhao; Yigui Tang; Jing Wang; Cai Wei; Fang Gu; Ting Lei; Zhiwu Chen; Yide Qin
Journal:  BMC Cancer       Date:  2016-03-24       Impact factor: 4.430

Review 4.  Cytotoxic and antitumor peptides as novel chemotherapeutics.

Authors:  Xin Luan; Ye Wu; Yi-Wen Shen; Hong Zhang; Yu-Dong Zhou; Hong-Zhuan Chen; Dale G Nagle; Wei-Dong Zhang
Journal:  Nat Prod Rep       Date:  2020-08-10       Impact factor: 15.111

Review 5.  Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action.

Authors:  Antimo Cutone; Luigi Rosa; Giusi Ianiro; Maria Stefania Lepanto; Maria Carmela Bonaccorsi di Patti; Piera Valenti; Giovanni Musci
Journal:  Biomolecules       Date:  2020-03-15

6.  Inhibition of breast cancer xenografts in a mouse model and the induction of apoptosis in multiple breast cancer cell lines by lactoferricin B peptide.

Authors:  Rizdwan Rahman; Alyssa Danielle Fonseka; Shiang-Chia Sua; Munirah Ahmad; Ramkumar Rajendran; Stephen Ambu; Fabian Davamani; Alan Soo-Beng Khoo; Ebenezer Chitra
Journal:  J Cell Mol Med       Date:  2021-07-08       Impact factor: 5.310
  6 in total

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