Literature DB >> 24963552

Implications of DNA leakage in eyes of mutant mice.

Alexander J Ogilvy1, Defen Shen, Yujuan Wang, Chi-Chao Chan, Mones S Abu-Asab.   

Abstract

Extranuclear DNA (enDNA) is not well studied ultrastructurally in the retinal pigment epithelium (RPE). We analyzed the retina and vastus medialis muscle of four mouse strains that are related to focal retinal degeneration by transmission electron microscopy (TEM) and EM immunolabeling. Evaluation of enDNA would imply the involvements of enDNA is either limited to the affected tissue or generalized in the whole body. Ultrastructural analysis and EM immunolabeling revealed that enDNA was present in the RPE cells but not in the muscle. These data suggest that enDNA could be unique to unhealthy RPE and a potential biomarker for cellular abnormality.

Entities:  

Keywords:  Autophagy; RPE; enDNA; extranuclear DNA; hypoxia; mitochondria; retinal pigment epithelium; vastus medialis

Mesh：

Substances：

Year:  2014        PMID： 24963552      PMCID： PMC4174997          DOI： 10.3109/01913123.2014.927406

Source DB:  PubMed          Journal:  Ultrastruct Pathol        ISSN： 0191-3123            Impact factor:   1.094


  19 in total

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Review 4.  Extrachromosomal circular DNA in eukaryotes: possible involvement in the plasticity of tandem repeats.

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7.  Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model.

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8.  NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration.

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