Michelle Veenstra1, Logan Danielson2, Evan Brownie2, May Saba3, Girija Natarajan4, Michael Klein5. 1. Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI. Electronic address: mveenstr@dmc.org. 2. Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI. 3. Department of Pharmacy, Children's Hospital of Michigan, Detroit, MI. 4. Division of Neonatal and Perinatal Medicine, Children's Hospital of Michigan, Detroit, MI. 5. Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI; Department of Surgery, Wayne State University School of Medicine, Detroit, MI.
Abstract
BACKGROUND: Newborns with necrotizing enterocolitis (NEC) are at high risk for the development of total parenteral nutritional-associated cholestasis (TPNAC). Patients with NEC were evaluated to determine risk factors for development of TPNAC and predictors of resolution. We hypothesized that there are additional factors relating to the timing of enteral nutrition or TPN components that effect development and persistence of TPNAC in patients with NEC that may be altered to decrease the chance of progression to liver failure. METHODS: This was a retrospective chart review of NEC patients from 2001 to 2010. TPNAC was defined as direct bilirubin ≥2 mg/dL, the level used for cholestasis in neonatal studies relating to TPNAC. RESULTS: Of 178 patients with NEC, 96 developed TPNAC, and in 27 TPNAC had resolved by discharge. Days of TPN did not affect TPNAC resolution by discharge (P = 1.0). TPNAC was less likely to occur in patients with body weights >1,500 g, enteral nutrition within the first week of life, no infection, fewer TPN days, and lesser hospital stay (P < .01). There were many factors affecting resolution of cholestasis. Enteral nutrition within 6 days of birth decreased development of TPNAC (P < .01), and resumption of enteral nutrition within 3 weeks after NEC diagnosis increased the resolution of cholestasis (P < .01). No component of TPN was important for the development or resolution of cholestasis. CONCLUSION: Of the factors that effect development and resolution of TPNAC in NEC, the ones that we can alter include early enteral feeds and surveillance for infection.
BACKGROUND: Newborns with necrotizing enterocolitis (NEC) are at high risk for the development of total parenteral nutritional-associated cholestasis (TPNAC). Patients with NEC were evaluated to determine risk factors for development of TPNAC and predictors of resolution. We hypothesized that there are additional factors relating to the timing of enteral nutrition or TPN components that effect development and persistence of TPNAC in patients with NEC that may be altered to decrease the chance of progression to liver failure. METHODS: This was a retrospective chart review of NEC patients from 2001 to 2010. TPNAC was defined as direct bilirubin ≥2 mg/dL, the level used for cholestasis in neonatal studies relating to TPNAC. RESULTS: Of 178 patients with NEC, 96 developed TPNAC, and in 27 TPNAC had resolved by discharge. Days of TPN did not affect TPNAC resolution by discharge (P = 1.0). TPNAC was less likely to occur in patients with body weights >1,500 g, enteral nutrition within the first week of life, no infection, fewer TPN days, and lesser hospital stay (P < .01). There were many factors affecting resolution of cholestasis. Enteral nutrition within 6 days of birth decreased development of TPNAC (P < .01), and resumption of enteral nutrition within 3 weeks after NEC diagnosis increased the resolution of cholestasis (P < .01). No component of TPN was important for the development or resolution of cholestasis. CONCLUSION: Of the factors that effect development and resolution of TPNAC in NEC, the ones that we can alter include early enteral feeds and surveillance for infection.
Authors: Yu Zheng Wu; Kathy Yuen Yee Chan; Kam Tong Leung; Hugh Simon Lam; Yuk Him Tam; Kim Hung Lee; Karen Li; Pak Cheung Ng Journal: FEBS Open Bio Date: 2021-06-01 Impact factor: 2.693
Authors: John D Watson; Tracy T Urban; Suhong S Tong; Jeanne Zenge; Ludmilla Khailova; Paul E Wischmeyer; Jesse A Davidson Journal: Front Pediatr Date: 2020-05-27 Impact factor: 3.418