Therese Dettenborn1, Kai Wermker2, Hans-Joachim Schulze3, Martin Klein4, Volker Schwipper4, Christian Hallermann3. 1. Department of Plastic Surgery (Head Dr. A. Krause-Bergmann), Fachklinik Hornheide, Dorbaumstrasse 300, 48157 Muenster, Germany. 2. Department of Oral and Cranio-Maxillofacial Surgery (Head: Prof. Dr. Dr. M. Klein), Head and Neck Cancer Centre, Fachklinik Hornheide, Dorbaumstrasse 300, 48157 Muenster, Germany. Electronic address: Kai.Wermker@fachklinik-hornheide.de. 3. Department of Dermatology and Histopathology (Head Priv.-Doz. Dr. H.-J. Schulze), Skin Cancer Centre, Fachklinik Hornheide, Dorbaumstrasse 300, 48157 Muenster, Germany. 4. Department of Oral and Cranio-Maxillofacial Surgery (Head: Prof. Dr. Dr. M. Klein), Head and Neck Cancer Centre, Fachklinik Hornheide, Dorbaumstrasse 300, 48157 Muenster, Germany.
Abstract
BACKGROUND: Cutaneous angiosarcoma of the head and neck (cAS-HN) is a rare malignancy with poor survival. Most of the histological markers and grading were not proven to be significant for prediction of outcomes in cAS-HN. This study aimed to find prognostic clinical features and histologic markers for cAS-HN. MATERIAL AND METHODS: We retrospectively analysed primary cAS-HN's seen in a single institution between 1980 and 2009. Clinical data and specific histologic characteristics were assessed. Outcome parameters were analysed using uni- and multivariate statistics. RESULTS: 80 patients (mean age 71.4 (SD 14.4) years, average follow-up time 55.3 (SD 74.4) months) were included. 5-year DSS rate was 62%. Univariate analysis revealed the extent of primary tumour (affecting more than one anatomical region), incomplete resection and initial metastatic disease as significant (p < 0.05) predictors for unfavourable disease specific survival (DSS) rates and time. Multivariate analysis confirmed age over 70 years, incomplete resection and initially distant metastasis influencing outcome adversely. Analysis of specific histological markers in 37 cases found patterns of growth (solid areas greater than 80%) associated with better survival (p = 0.011). CONCLUSION: In conclusion age, number of affected regions, initial metastasis, complete initial resection and pattern of growth significantly affected mortality rates.
BACKGROUND:Cutaneous angiosarcoma of the head and neck (cAS-HN) is a rare malignancy with poor survival. Most of the histological markers and grading were not proven to be significant for prediction of outcomes in cAS-HN. This study aimed to find prognostic clinical features and histologic markers for cAS-HN. MATERIAL AND METHODS: We retrospectively analysed primary cAS-HN's seen in a single institution between 1980 and 2009. Clinical data and specific histologic characteristics were assessed. Outcome parameters were analysed using uni- and multivariate statistics. RESULTS: 80 patients (mean age 71.4 (SD 14.4) years, average follow-up time 55.3 (SD 74.4) months) were included. 5-year DSS rate was 62%. Univariate analysis revealed the extent of primary tumour (affecting more than one anatomical region), incomplete resection and initial metastatic disease as significant (p < 0.05) predictors for unfavourable disease specific survival (DSS) rates and time. Multivariate analysis confirmed age over 70 years, incomplete resection and initially distant metastasis influencing outcome adversely. Analysis of specific histological markers in 37 cases found patterns of growth (solid areas greater than 80%) associated with better survival (p = 0.011). CONCLUSION: In conclusion age, number of affected regions, initial metastasis, complete initial resection and pattern of growth significantly affected mortality rates.
Authors: Jun Ho Choi; Kyung Chan Ahn; Hak Chang; Kyung Won Minn; Ung Sik Jin; Byung Jun Kim Journal: Biomed Res Int Date: 2015-12-02 Impact factor: 3.411