| Literature DB >> 24960604 |
Stéphane Oudard1, Antoine Angelergues1.
Abstract
Cabazitaxel, a next-generation taxane, retains its efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC) who progress on new androgen receptor (AR)-targeted agents such as abiraterone acetate or enzalutamide. These findings are reinforced by in vitro preclinical data confirming cross-resistance between abiraterone and enzalutamide, but not between cabazitaxel and AR-targeted agents.Entities:
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Year: 2014 PMID: 24960604 DOI: 10.1038/nrurol.2014.144
Source DB: PubMed Journal: Nat Rev Urol ISSN: 1759-4812 Impact factor: 14.432