Literature DB >> 24960290

AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.

Juxiang Huang1, Lin Wang2, Minghu Jiang3, Qingchun Chen4, Zhenfu Jiang5, Haitao Feng6.   

Abstract

7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease databases, we determined AGR2-mediated lung adenocarcinoma metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1. Thus we proposed AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anterior gradient homolog 2 (AGR2); Humoral immune response; Lung adenocarcinoma; Mechanism

Mesh：

Substances：

Year:  2014        PMID： 24960290     DOI： 10.1016/j.cellimm.2014.05.008

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  5 in total

1.  Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384.

Authors:  Juxiang Huang; Lin Wang; Minghu Jiang; Qingchun Chen; Xiaoyu Zhang; Yangming Wang; Zhenfu Jiang; Zhongjie Zhang
Journal:  Immunol Res       Date:  2016-04       Impact factor: 2.829

2.  High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.

Authors:  Huilei Zhou; Lin Wang; Juxiang Huang; Minghu Jiang; Xiaoyu Zhang; Liyuan Zhang; Yangming Wang; Zhenfu Jiang; Zhongjie Zhang
Journal:  J Cancer       Date:  2015-04-05       Impact factor: 4.207

3.  Downregulation of AGR2, p21, and cyclin D and alterations in p53 function were associated with tumor progression and chemotherapy resistance in epithelial ovarian carcinoma.

Authors:  Mariana Rezende Alves; Natalia Cruz E Melo; Mateus Camargo Barros-Filho; Nayra Soares do Amaral; Felipe Ilelis de Barros Silva; Glauco Baiocchi Neto; Fernando Augusto Soares; Louise de Brot Andrade; Rafael Malagoli Rocha
Journal:  Cancer Med       Date:  2018-05-29       Impact factor: 4.452

4.  High expression of AGR2 in lung cancer is predictive of poor survival.

Authors:  Mohammed Alavi; Vei Mah; Erin L Maresh; Lora Bagryanova; Steve Horvath; David Chia; Lee Goodglick; Alvin Y Liu
Journal:  BMC Cancer       Date:  2015-10-06       Impact factor: 4.430

5.  Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration.

Authors:  Hitesh Bhagavanbhai Mangukiya; Hema Negi; Siva Bharath Merugu; Qudsia Sehar; Dhahiri Saidi Mashausi; Fakhar-Un-Nisa Yunus; Zhenghua Wu; Dawei Li
Journal:  Cell Adh Migr       Date:  2019-12       Impact factor: 3.405
  5 in total

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