Literature DB >> 24959488

An unusually long survival of a patient with glioblastoma of spinal cord: a case report.

Sunitha Susan Varghese1, Patricia Sebastian1, Vivek Joseph2, Geeta Chacko3, Selvamani Backianathan4.   

Abstract

Primary glioblastoma of spinal cord are rare and are associated with poor survival especially in adults. We report a case of glioblastoma of thoracic spinal cord (D3 to D6) in an adult treated with partial resection surgery and radiation therapy with a survival of six years with good quality of life. The patient had paraplegia at presentation but improved after surgery and radiation therapy to grade 4 in both lower limbs. After 5 years, he developed new lesion in a different location of the spine (L1, L2 & L5) along with multiple lesions over entire spine and was treated with radiation therapy and a year later developed a new lesion intracranially in the posterior fossa involving cerebellopontine angle region infiltrating brainstem. He was treated with palliative radiotherapy and is on chemotherapy with Temozolomide and is still alive with ability to do activities of daily living at the time of this report. Radiation therapy provided prolonged local control with effective palliation of symptoms and good quality of life in this patient enabling to do activities of daily living.

Entities:  

Keywords:  Glioblastoma; Spinal cord; Survival

Year:  2014        PMID: 24959488      PMCID: PMC4064906          DOI: 10.7860/JCDR/2014/8486.4218

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  10 in total

Review 1.  Radiation therapy and the management of intramedullary spinal cord tumors.

Authors:  S R Isaacson
Journal:  J Neurooncol       Date:  2000-05       Impact factor: 4.130

2.  A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy.

Authors:  G B Rodrigues; J N Waldron; C S Wong; N J Laperriere
Journal:  Int J Radiat Oncol Biol Phys       Date:  2000-10-01       Impact factor: 7.038

3.  Spinal cord gliomas: A multi-institutional retrospective analysis.

Authors:  May Abdel-Wahab; Blessing Etuk; James Palermo; Hiroki Shirato; John Kresl; Ozlem Yapicier; Gail Walker; Bernd W Scheithauer; Edward Shaw; Charles Lee; Walter Curran; Terry Thomas; Arnold Markoe
Journal:  Int J Radiat Oncol Biol Phys       Date:  2005-12-20       Impact factor: 7.038

4.  Recurrent spinal cord glioblastoma: salvage therapy with bevacizumab.

Authors:  Marc C Chamberlain; Sandra K Johnston
Journal:  J Neurooncol       Date:  2010-08-01       Impact factor: 4.130

5.  Prognostic factors and survival in primary malignant astrocytomas of the spinal cord: a population-based analysis from 1973 to 2007.

Authors:  Hadie Adams; Javier Avendaño; Shaan M Raza; Ziya L Gokaslan; George I Jallo; Alfredo Quiñones-Hinojosa
Journal:  Spine (Phila Pa 1976)       Date:  2012-05-20       Impact factor: 3.468

Review 6.  Adult primary intradural spinal cord tumors: a review.

Authors:  Marc C Chamberlain; Trent L Tredway
Journal:  Curr Neurol Neurosci Rep       Date:  2011-06       Impact factor: 5.081

7.  Postoperative radiotherapy of primary spinal cord tumors.

Authors:  D E Linstadt; W M Wara; S A Leibel; P H Gutin; C B Wilson; G E Sheline
Journal:  Int J Radiat Oncol Biol Phys       Date:  1989-06       Impact factor: 7.038

8.  Temozolomide or bevacizumab for spinal cord high-grade gliomas.

Authors:  Thomas J Kaley; Ijah Mondesire-Crump; Igor T Gavrilovic
Journal:  J Neurooncol       Date:  2012-06-08       Impact factor: 4.130

9.  Prognosis and treatment of spinal cord astrocytoma.

Authors:  Kiernan J Minehan; Paul D Brown; Bernd W Scheithauer; William E Krauss; Michael P Wright
Journal:  Int J Radiat Oncol Biol Phys       Date:  2008-08-05       Impact factor: 7.038

10.  The role of radiotherapy in the management of spinal cord glioma.

Authors:  H Shirato; T Kamada; K Hida; I Koyanagi; Y Iwasaki; K Miyasaka; H Abe
Journal:  Int J Radiat Oncol Biol Phys       Date:  1995-09-30       Impact factor: 7.038

  10 in total

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