Sir,The report on “β-thalassemia and alkaptonuria” is very interesting.[1] Lodh and Kerketta reported a case of the combination of β-thalassemia and alkaptonuria and mentioned that this was the first case report. In fact, the two condition might be co-exist but has not been clearly mentioned. In the area with high endemic rate of thalassemia, the occurrence of alkaptouria has ever been reported.[2] The diagnosis of the problem can be easily forgotten and overlooked in case that the technique for diagnosis is not available.[3] Based on the report of Lodh and Kerketta the remained question is whether the implementation of universal genetic screening that includes thalassemia and alkaptonuria screening should be considered of not.