Literature DB >> 24958526

In search of a surrogate: engineering human beta cell lines for therapy.

Brittney N Newby1, Naohiro Terada1, Clayton E Mathews2.   

Abstract

Replacement of insulin-producing cells is a promising therapy for the restoration of the beta cell mass that is destroyed in patients with type 1 diabetes (T1D). However, the use of large amounts of islets per transplant, coupled with the scarcity of donor tissue, diminishes its feasibility. Here we briefly discuss current progress in developing ideal functional beta cells as well as the rationale for developing renewable sources of insulin-producing cells that can be transplanted.
Copyright © 2014. Published by Elsevier Ltd.

Entities:  

Keywords:  beta cells; embryonic stem cell; induced pluripotent stem cell; islet cell transplantation; type 1 diabetes

Mesh：

Year:  2014        PMID： 24958526      PMCID： PMC4151247          DOI： 10.1016/j.tem.2014.05.006

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  16 in total

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Authors:  Josipa Bilic; Juan Carlos Izpisua Belmonte
Journal:  Stem Cells       Date:  2012-01       Impact factor: 6.277

Review 2.  Concise review: in search of unlimited sources of functional human pancreatic beta cells.

Authors:  Raphael Scharfmann; Latif Rachdi; Philippe Ravassard
Journal:  Stem Cells Transl Med       Date:  2012-12-19       Impact factor: 6.940

3.  A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion.

Authors:  Philippe Ravassard; Yasmine Hazhouz; Séverine Pechberty; Emilie Bricout-Neveu; Mathieu Armanet; Paul Czernichow; Raphael Scharfmann
Journal:  J Clin Invest       Date:  2011-08-25       Impact factor: 14.808

4.  Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4.

Authors:  Srividya Vasu; Neville H McClenaghan; Jane T McCluskey; Peter R Flatt
Journal:  Biochim Biophys Acta       Date:  2013-09-01

Review 5.  How to make a functional β-cell.

Authors:  Felicia W Pagliuca; Douglas A Melton
Journal:  Development       Date:  2013-06       Impact factor: 6.868

Review 6.  The use of stem cells for pancreatic regeneration in diabetes mellitus.

Authors:  Luc Bouwens; Isabelle Houbracken; Josue K Mfopou
Journal:  Nat Rev Endocrinol       Date:  2013-07-23       Impact factor: 43.330

Review 7.  Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines.

Authors:  Yaíma L Lightfoot; Jing Chen; Clayton E Mathews
Journal:  Eur J Clin Invest       Date:  2012-08-25       Impact factor: 4.686

Review 8.  Type 1 diabetes.

Authors:  Mark A Atkinson; George S Eisenbarth; Aaron W Michels
Journal:  Lancet       Date:  2013-07-26       Impact factor: 79.321

9.  Development of a conditionally immortalized human pancreatic β cell line.

Authors:  Raphaël Scharfmann; Severine Pechberty; Yasmine Hazhouz; Manon von Bülow; Emilie Bricout-Neveu; Maud Grenier-Godard; Fanny Guez; Latif Rachdi; Matthias Lohmann; Paul Czernichow; Philippe Ravassard
Journal:  J Clin Invest       Date:  2014-03-25       Impact factor: 14.808

Review 10.  Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials.

Authors:  Teodora P Staeva; Lucienne Chatenoud; Richard Insel; Mark A Atkinson
Journal:  Diabetes       Date:  2013-01       Impact factor: 9.461
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  5 in total

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Authors:  T Kushibiki; S Okawa; T Hirasawa; M Ishihara
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2.  Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.

Authors:  Bryndon J Oleson; Jennifer A McGraw; Katarzyna A Broniowska; Mani Annamalai; Jing Chen; Justin R Bushkofsky; Dawn B Davis; John A Corbett; Clayton E Mathews
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-06-17       Impact factor: 3.619

3.  A human beta cell line with drug inducible excision of immortalizing transgenes.

Authors:  Marion Benazra; Marie-José Lecomte; Claire Colace; Andreas Müller; Cécile Machado; Severine Pechberty; Emilie Bricout-Neveu; Maud Grenier-Godard; Michele Solimena; Raphaël Scharfmann; Paul Czernichow; Philippe Ravassard
Journal:  Mol Metab       Date:  2015-10-20       Impact factor: 7.422

4.  Immunogenicity of human embryonic stem cell-derived beta cells.

Authors:  Cornelis R van der Torren; Arnaud Zaldumbide; Gaby Duinkerken; Simone H Brand-Schaaf; Mark Peakman; Geert Stangé; Laura Martinson; Evert Kroon; Eugene P Brandon; Daniel Pipeleers; Bart O Roep
Journal:  Diabetologia       Date:  2016-10-27       Impact factor: 10.122

5.  Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate.

Authors:  Valeria Perugini; Samuel M Flaherty; Matteo Santin
Journal:  J Mater Sci Mater Med       Date:  2022-04-11       Impact factor: 4.727
  5 in total

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