Literature DB >> 24958193

Fragile X gene expansions are not associated with dementia.

Deborah A Hall1, David A Bennett2, Christopher M Filley3, Raj C Shah2, Benzi Kluger4, Bichun Ouyang5, Elizabeth Berry-Kravis6.   

Abstract

The purpose of this study was to determine the frequency of fragile X mental retardation 1 (FMR1) premutation size expansions in individuals with Alzheimer's disease (AD) and other cognitive disorders compared with control subjects. FMR1 genetic screening was completed in patients being seen in a neurobehavioral or AD clinics. Appropriate controls were also collected. A second cohort was a community based, autopsy confirmed, sample of individuals with normal cognitive function, mild cognitive impairment, or AD. There was not an increased frequency of FMR1 expansions in individuals with cognitive disorders, including AD, compared with control subjects.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; FMR1; Fragile X

Mesh：

Substances：

Year:  2014        PMID： 24958193      PMCID： PMC4273643          DOI： 10.1016/j.neurobiolaging.2014.04.027

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  5 in total

Review 1.  Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links.

Authors:  D K Sokol; B Maloney; J M Long; B Ray; D K Lahiri
Journal:  Neurology       Date:  2011-04-12       Impact factor: 9.910

2.  Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS).

Authors:  D A Hall; E Berry-Kravis; S Jacquemont; C D Rice; J Cogswell; L Zhang; R J Hagerman; P J Hagerman; M A Leehey
Journal:  Neurology       Date:  2005-07-26       Impact factor: 9.910

3.  Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS.

Authors:  F Tassone; C M Greco; M R Hunsaker; A L Seritan; R F Berman; L W Gane; S Jacquemont; K Basuta; L-W Jin; P J Hagerman; R J Hagerman
Journal:  Genes Brain Behav       Date:  2012-04-06       Impact factor: 3.449

4.  Dementia in fragile X-associated tremor/ataxia syndrome (FXTAS): comparison with Alzheimer's disease.

Authors:  Andreea L Seritan; Danh V Nguyen; Sarah Tomaszewski Farias; Ladson Hinton; Jim Grigsby; James A Bourgeois; Randi J Hagerman
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-10-05       Impact factor: 3.568

5.  Screening for FXTAS in 95 Spanish patients negative for Huntington disease.

Authors:  Laia Rodriguez-Revenga; M Mònica Santos; Aurora Sánchez; Montserrat Pujol; Beatriz Gómez-Anson; Celia Badenas; Dolores Jiménez; Irene Madrigal; Montserrat Milà
Journal:  Genet Test       Date:  2008-03
  5 in total
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Journal:  Ann N Y Acad Sci       Date:  2015-01-26       Impact factor: 5.691

2.  Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series.

Authors:  Sarah M Debrey; Maureen A Leehey; Olga Klepitskaya; Christopher M Filley; Raj C Shah; Benzi Kluger; Elizabeth Berry-Kravis; Elaine Spector; Flora Tassone; Deborah A Hall
Journal:  Cerebellum       Date:  2016-10       Impact factor: 3.847

Review 3.  Religious Orders Study and Rush Memory and Aging Project.

Authors:  David A Bennett; Aron S Buchman; Patricia A Boyle; Lisa L Barnes; Robert S Wilson; Julie A Schneider
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

4.  Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers.

Authors:  Giovanni Lugli; Aaron M Cohen; David A Bennett; Raj C Shah; Christopher J Fields; Alvaro G Hernandez; Neil R Smalheiser
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5.  Fragile X mental retardation protein expression in Alzheimer's disease.

Authors:  Abigail J Renoux; Nicholas M Carducci; Arya A Ahmady; Peter K Todd
Journal:  Front Genet       Date:  2014-10-21       Impact factor: 4.599

6.  FMR1 Low Zone CGG Repeats: Phenotypic Associations in the Context of Parenting Stress.

Authors:  Marsha R Mailick; Jinkuk Hong; Leann Smith DaWalt; Jan S Greenberg; Arezoo Movaghar; Mei Wang Baker; Paul J Rathouz; Murray H Brilliant
Journal:  Front Pediatr       Date:  2020-05-14       Impact factor: 3.418
  6 in total

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