Literature DB >> 2495794

Evidence for altered expression of the GTP-dependent regulatory proteins, Gs and Gi, in adipocytes from aged rats.

A Green1, J L Johnson.   

Abstract

The alpha-subunits of Gi and Gs were quantified in adipocyte membranes from young (2-month) and older (18-month) rats by pertussis-toxin and cholera-toxin labelling respectively. Aging was associated with a 3-fold increase in Gi alpha-subunit, but only a 2-fold increase in one of the two Gs alpha-subunit species labelled. The findings may explain the altered sensitivity of adipocytes from aged rats to lipolytic and anti-lipolytic stimuli.

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Year:  1989        PMID： 2495794      PMCID： PMC1138404          DOI： 10.1042/bj2580607

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

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Journal:  J Biol Chem       Date:  1964-02       Impact factor: 5.157

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Journal:  Eur J Biochem       Date:  1978-10

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Authors:  A C Newby; J P Luzio; C N Hales
Journal:  Biochem J       Date:  1975-03       Impact factor: 3.857

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Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

6.  Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.

Authors:  R Iyengar; K A Rich; J T Herberg; D Grenet; S Mumby; J Codina
Journal:  J Biol Chem       Date:  1987-07-05       Impact factor: 5.157

Review 7.  G proteins: transducers of receptor-generated signals.

Authors:  A G Gilman
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

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Authors:  R Ebert; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

9.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 10.  Catecholamines and cardiovascular function in aging.

Authors:  E G Lakatta
Journal:  Endocrinol Metab Clin North Am       Date:  1987-12       Impact factor: 4.741
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  3 in total

1.  Levels of G-proteins in liver and brain of lean and obese (ob/ob) mice.

Authors:  N McFarlane-Anderson; J Bailly; N Bégin-Heick
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

2.  Quantification of the alpha and beta subunits of the transducing elements (Gs and Gi) of adenylate cyclase in adipocyte membranes from lean and obese (ob/ob) mice.

Authors:  N Bégin-Heick
Journal:  Biochem J       Date:  1990-05-15       Impact factor: 3.857

3.  Effects of litter removal on the lipolytic response and the regulatory components of the adenylate cyclase in adipocytes isolated from lactating rats.

Authors:  M Ros; G Alonso; F J Moreno
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857
  3 in total

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