Jean-Jacques Dubost1, Marion Couderc2, Zuzana Tatar2, Anne Tournadre2, Julien Lopez2, Sylvain Mathieu2, Martin Soubrier2. 1. Service de Rhumatologie, Hôpital G.-Monpied, Université Clermont-Ferrand 1, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France. Electronic address: jjdubost@chu-clermontferrand.fr. 2. Service de Rhumatologie, Hôpital G.-Monpied, Université Clermont-Ferrand 1, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France.
Abstract
OBJECTIVE: A rise in the incidence of septic arthritis due to methicillin-resistant Staphylococcus aureus (MRSA) has been reported in several parts of the world. Here, our objective was to look for changes over the last 30years in the distribution and antibiotic susceptibility profiles of organisms responsible for septic arthritis. METHODS: We conducted a single-center retrospective study of all cases of septic arthritis documented by joint specimens and/or blood cultures between 1979 and 2008. Prosthetic joint infections were excluded. RESULTS: We enrolled 374 patients, of whom 127, 136, and 111 were included during each decade, respectively. We detected no significant time trends in the proportions of staphylococci (67%, 65%, and 64%), streptococci (14%, 21%, and 17%), or Gram-negative rods (7%, 10%, and 14%). Tuberculosis was more common during the earliest decade (1979-1988, n=10, 4, 2%; P<0.05). No significant changes occurred in the proportions of methicillin-resistant staphylococci or MRSA (13%, 11%, 15%). Age and prevalence of risk factors for infection increased over time. CONCLUSION: The distribution and susceptibility of organisms causing septic arthritis has changed little over time. Our findings do not support the use of broader-spectrum antibiotics when empirical treatment is deemed necessary at our center.
OBJECTIVE: A rise in the incidence of septic arthritis due to methicillin-resistant Staphylococcus aureus (MRSA) has been reported in several parts of the world. Here, our objective was to look for changes over the last 30years in the distribution and antibiotic susceptibility profiles of organisms responsible for septic arthritis. METHODS: We conducted a single-center retrospective study of all cases of septic arthritis documented by joint specimens and/or blood cultures between 1979 and 2008. Prosthetic joint infections were excluded. RESULTS: We enrolled 374 patients, of whom 127, 136, and 111 were included during each decade, respectively. We detected no significant time trends in the proportions of staphylococci (67%, 65%, and 64%), streptococci (14%, 21%, and 17%), or Gram-negative rods (7%, 10%, and 14%). Tuberculosis was more common during the earliest decade (1979-1988, n=10, 4, 2%; P<0.05). No significant changes occurred in the proportions of methicillin-resistant staphylococci or MRSA (13%, 11%, 15%). Age and prevalence of risk factors for infection increased over time. CONCLUSION: The distribution and susceptibility of organisms causing septic arthritis has changed little over time. Our findings do not support the use of broader-spectrum antibiotics when empirical treatment is deemed necessary at our center.
Authors: Joan M Nolla; Oscar Murillo; Javier Narvaez; Carmen Gómez Vaquero; Jaime Lora-Tamayo; Salvador Pedrero; Javier Cabo; Javier Ariza Journal: Medicine (Baltimore) Date: 2016-06 Impact factor: 1.889
Authors: Shuting Sun; Jianguo Tao; Parish P Sedghizadeh; Philip Cherian; Adam F Junka; Esmat Sodagar; Lianping Xing; Robert K Boeckman; Venkatesan Srinivasan; Zhenqiang Yao; Brendan F Boyce; Brea Lipe; Jeffrey D Neighbors; R Graham G Russell; Charles E McKenna; Frank H Ebetino Journal: Br J Pharmacol Date: 2021-04-10 Impact factor: 8.739