| Literature DB >> 24956157 |
Marco Paolino1, Laura Mennuni, Germano Giuliani, Maurizio Anzini, Marco Lanza, Gianfranco Caselli, Chiara Galimberti, Maria Cristina Menziani, Alessandro Donati, Andrea Cappelli.
Abstract
Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar Ki value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor.Entities:
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Year: 2014 PMID： 24956157 DOI： 10.1039/c4cc02502d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222