Literature DB >> 24956071

From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.

S Desrat1, C Remeur, C Gény, G Rivière, C Colas, V Dumontet, N Birlirakis, B I Iorga, F Roussi.   

Abstract

The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.

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Year:  2014        PMID： 24956071     DOI： 10.1039/c4cc01830c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Regio- and Stereoselective Synthesis of 1,2-Dihaloalkenes Using In-Situ-Generated ICl, IBr, BrCl, I2, and Br2.

Authors:  Xiaojun Zeng; Shiwen Liu; Yuhao Yang; Yi Yang; Gerald B Hammond; Bo Xu
Journal:  Chem       Date:  2020-04-09       Impact factor: 22.804

Review 2.  Targeting MCL-1 in hematologic malignancies: Rationale and progress.

Authors:  Andrew H Wei; Andrew W Roberts; Andrew Spencer; Aaron Seth Rosenberg; David Siegel; Roland B Walter; Sean Caenepeel; Paul Hughes; Zach McIver; Khalid Mezzi; Phuong Khanh Morrow; Anthony Stein
Journal:  Blood Rev       Date:  2020-02-21       Impact factor: 8.250

Review 3.  Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1.

Authors:  Andrew M Beekman; Lesley A Howell
Journal:  ChemMedChem       Date:  2015-12-23       Impact factor: 3.466

Review 4.  Strategies to Reduce the On-Target Platelet Toxicity of Bcl-xL Inhibitors: PROTACs, SNIPERs and Prodrug-Based Approaches.

Authors:  Arvind Negi; Anne Sophie Voisin-Chiret
Journal:  Chembiochem       Date:  2022-03-19       Impact factor: 3.461
  4 in total

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