Robin E A Tjon Pian Gi1,2, Michel R M San Giorgi1,2, Lorian Slagter-Menkema1,3,2, Bettien M van Hemel3,2, Bernard F A M van der Laan1,2, Edwin R van den Heuvel4,2, Frederik G Dikkers1,2, Ed M D Schuuring3,2. 1. Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 2. Graduate School of Medical Sciences (Groningen University Institute for Drug Exploration), University of Groningen, The Netherlands. 3. Department of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 4. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Abstract
BACKGROUND: Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV)6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP. METHODS: A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies. RESULTS: Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (<22.4 years) HPV11 group, and the older age (<22.4 years) HPV6 group. Regardless of HPV type, earlier age of onset of RRP resulted in a higher number of surgical interventions. CONCLUSION: Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP.
BACKGROUND: Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV)6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP. METHODS: A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies. RESULTS: Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (<22.4 years) HPV11 group, and the older age (<22.4 years) HPV6 group. Regardless of HPV type, earlier age of onset of RRP resulted in a higher number of surgical interventions. CONCLUSION: Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP.
Authors: Mateja M Jelen; Zigui Chen; Boštjan J Kocjan; Lea Hošnjak; Felicity J Burt; Paul K S Chan; Diego Chouhy; Catharina E Combrinck; Christine Estrade; Alison Fiander; Suzanne M Garland; Adriana A Giri; Joaquín Víctor González; Arndt Gröning; Sam Hibbitts; Tommy N M Luk; Karina Marinic; Toshihiko Matsukura; Anna Neumann; Anja Oštrbenk; Maria Alejandra Picconi; Martin Sagadin; Roland Sahli; Riaz Y Seedat; Katja Seme; Alberto Severini; Jessica L Sinchi; Jana Smahelova; Sepehr N Tabrizi; Ruth Tachezy; Sarah Tohme Faybush; Virgilijus Uloza; Ingrida Uloziene; Yong Wee Wong; Snježana Židovec Lepej; Robert D Burk; Mario Poljak Journal: J Virol Date: 2016-05-12 Impact factor: 5.103
Authors: Christoph Arens; Cesare Piazza; Mario Andrea; Frederik G Dikkers; Robin E A Tjon Pian Gi; Susanne Voigt-Zimmermann; Giorgio Peretti Journal: Eur Arch Otorhinolaryngol Date: 2015-12-17 Impact factor: 2.503
Authors: Klaas Mensaert; Wim Van Criekinge; Olivier Thas; Ed Schuuring; Renske D M Steenbergen; G Bea A Wisman; Tim De Meyer Journal: Front Genet Date: 2015-02-04 Impact factor: 4.599
Authors: Mary C Bedard; Alessandro de Alarcon; Yann-Fuu Kou; David Lee; Alexandra Sestito; Angela L Duggins; Marion Brusadelli; Adam Lane; Kathryn A Wikenheiser-Brokamp; Susanne I Wells; David F Smith Journal: Cancers (Basel) Date: 2021-05-23 Impact factor: 6.639
Authors: Robin E A Tjon Pian Gi; Michel R M San Giorgi; Michael Pawlita; Angelika Michel; Bettien M van Hemel; Ed M D Schuuring; Edwin R van den Heuvel; Bernard F A M van der Laan; Frederik G Dikkers Journal: Eur Arch Otorhinolaryngol Date: 2016-05-17 Impact factor: 2.503