Ran Cui1, Bin Su1, Chunjun Sheng1, Xiaoyun Cheng1, Peng Yang1, Le Bu1, Hong Li1, Jiying Wang1, Hui Sheng2, Shen Qu1. 1. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China. 2. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China ; Advanced Institute of Translational Medicine, Tongji University Shanghai 200092, China.
Abstract
OBJECTIVE: To investigate the relationship between total osteocalcin (total OC) and testosterone level in the serum of male patients with type 2 diabetes mellitus (T2DM). METHODS: 98 male T2DM were recruited in our cross-section study. Their anthropometric parameters were measured and body mass index (BMI) was calculated. Serum markers including glucose, insulin, HbA1c, testosterone, total OC and other bone metabolic markers were examined. Simple Pearson correlation and multiple regression analysis were performed. RESULTS: Poor level of glucose control was found in the patients (HbA1c 9.19±2.53 and FPG 8.20±2.98). In simple Pearson correlation, total OC was positively related with testosterone (r=0.236, P=0.019), and this relation still existed after considering all the parameters of the patients (Model 1, 2 and 3). CONCLUSION: In male patients with T2DM, total OC was positively correlated with testosterone, so total OC might predict the testosterone level in the serum.
OBJECTIVE: To investigate the relationship between total osteocalcin (total OC) and testosterone level in the serum of male patients with type 2 diabetes mellitus (T2DM). METHODS: 98 male T2DM were recruited in our cross-section study. Their anthropometric parameters were measured and body mass index (BMI) was calculated. Serum markers including glucose, insulin, HbA1c, testosterone, total OC and other bone metabolic markers were examined. Simple Pearson correlation and multiple regression analysis were performed. RESULTS: Poor level of glucose control was found in the patients (HbA1c 9.19±2.53 and FPG 8.20±2.98). In simple Pearson correlation, total OC was positively related with testosterone (r=0.236, P=0.019), and this relation still existed after considering all the parameters of the patients (Model 1, 2 and 3). CONCLUSION: In male patients with T2DM, total OC was positively correlated with testosterone, so total OC might predict the testosterone level in the serum.
Entities:
Keywords:
Osteocalcin; testosterone; type 2 diabetes mellitus; undercarboxylated osteocalcin
Authors: Sandeep Dhindsa; Michael G Miller; Cecilia L McWhirter; Donald E Mager; Husam Ghanim; Ajay Chaudhuri; Paresh Dandona Journal: Diabetes Care Date: 2010-03-03 Impact factor: 19.112