Literature DB >> 24954777

Sir John Gurdon: father of nuclear reprogramming.

Helen M Blau1.   

Abstract

Sir John Gurdon founded the field of nuclear reprogramming. His work set the stage for the ever burgeoning area of stem cell biology and regenerative medicine. Here I provide personal reflections on times I shared with John Gurdon and professional reflections of the impact of his ground-breaking research on my own development as a scientist and on the field in general. His paradigm-shifting experiments will continue to provoke scientists to think outside the box for many years to come.
Copyright © 2014 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cell fusion; Cell plasticity; Cloning; Heterokaryons; Nuclear reprogramming

Mesh:

Year:  2014        PMID: 24954777      PMCID: PMC4350676          DOI: 10.1016/j.diff.2014.05.002

Source DB:  PubMed          Journal:  Differentiation        ISSN: 0301-4681            Impact factor:   3.880


  17 in total

1.  A community effect in muscle development.

Authors:  J B Gurdon; E Tiller; J Roberts; K Kato
Journal:  Curr Biol       Date:  1993-01       Impact factor: 10.834

2.  Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs.

Authors:  R Briggs; T J King
Journal:  Proc Natl Acad Sci U S A       Date:  1952-05       Impact factor: 11.205

3.  Plasticity of the differentiated state.

Authors:  H M Blau; G K Pavlath; E C Hardeman; C P Chiu; L Silberstein; S G Webster; S C Miller; C Webster
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

4.  Viable offspring derived from fetal and adult mammalian cells.

Authors:  I Wilmut; A E Schnieke; J McWhir; A J Kind; K H Campbell
Journal:  Nature       Date:  1997-02-27       Impact factor: 49.962

5.  5-Azacytidine permits gene activation in a previously noninducible cell type.

Authors:  C P Chiu; H M Blau
Journal:  Cell       Date:  1985-02       Impact factor: 41.582

6.  A community effect in animal development.

Authors:  J B Gurdon
Journal:  Nature       Date:  1988 Dec 22-29       Impact factor: 49.962

7.  Behavior of differentiated hen nuclei in the cytoplasm of rat myoblasts and myotubules.

Authors:  S A Carlsson; R E Savage; N R Ringertz
Journal:  Nature       Date:  1970-11-28       Impact factor: 49.962

8.  Gene dosage dependence of pigment synthesis in melanoma x fibroblast hybrids (hamster cells-mouse fibroblast-DOPA-oxidase-irradiation).

Authors:  C Fougère; F Ruiz; B Ephrussi
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

9.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

10.  Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes.

Authors:  M C Weiss; M Chaplain
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

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