Suvarna Shinde1, Nandkishor S Kabra, Shobha R Sharma, Bhupendra S Avasthi, Javed Ahmed. 1. Department of Neonatology, Surya Childrens Hospital, Santacruz West, Mumbai, India. Correspondence to: Dr Nandkishor S Kabra, Department of Neonatology, Surya Childrens Hospital, Mangal Ashirwad, Junction of S V Road and Dattatraya Road, Santacruz West, Mumbai 400054 India. nskabra@gmail.com.
Abstract
OBJECTIVE: To compare the efficacy of glycerin suppository versus no suppository in preterm very-low-birthweight neonates for improving feeding tolerance. DESIGN: Randomized controlled trial. SETTING: Level III neonatal unit from Mumbai, India. PARTICIPANTS: 50 very-low-birthweight (birth weight between 1000 to 1500 grams)preterm (gestational age between 28 to 32 weeks) neonates randomized to glycerine suppository (n=25) or no intervention (n=26). INTERVENTION: Glycerin suppository (1g) once a day from day-2 to day-14 of life or no suppository, along with intermittent oral feeds and standardized care. PRIMARY OUTCOME: Time required to achieve full enteral feeds (180 mL/kg/d). RESULTS: Baseline characteristics of neonates like gestational age, birthweight, gender and age at the time of introduction of feeds were comparable in both groups. The mean (SD) duration to reach full enteral feed was 11.90 (3.1) days in glycerin suppository group and was not significantly different (P=0.58) from control group, [11.33 (3.57) days]. Glycerin suppository group regained birth weight 2 days earlier than control group but this difference was not significant (P=0.16). There was no significant difference in duration of hospital stay or occurrence of necrotizing enterocolitis amongst the two study groups. CONCLUSIONS: Once daily application of glycerin suppository does not accelerate the achievement of full feeds in preterm very-low-birthweight neonates.
RCT Entities:
OBJECTIVE: To compare the efficacy of glycerin suppository versus no suppository in preterm very-low-birthweight neonates for improving feeding tolerance. DESIGN: Randomized controlled trial. SETTING: Level III neonatal unit from Mumbai, India. PARTICIPANTS: 50 very-low-birthweight (birth weight between 1000 to 1500 grams)preterm (gestational age between 28 to 32 weeks) neonates randomized to glycerine suppository (n=25) or no intervention (n=26). INTERVENTION: Glycerin suppository (1g) once a day from day-2 to day-14 of life or no suppository, along with intermittent oral feeds and standardized care. PRIMARY OUTCOME: Time required to achieve full enteral feeds (180 mL/kg/d). RESULTS: Baseline characteristics of neonates like gestational age, birthweight, gender and age at the time of introduction of feeds were comparable in both groups. The mean (SD) duration to reach full enteral feed was 11.90 (3.1) days in glycerin suppository group and was not significantly different (P=0.58) from control group, [11.33 (3.57) days]. Glycerin suppository group regained birth weight 2 days earlier than control group but this difference was not significant (P=0.16). There was no significant difference in duration of hospital stay or occurrence of necrotizing enterocolitis amongst the two study groups. CONCLUSIONS: Once daily application of glycerin suppository does not accelerate the achievement of full feeds in preterm very-low-birthweight neonates.
Authors: Michael H Livingston; Jorge Zequeira; Henrietta Blinder; Julia Pemberton; Connie Williams; J Mark Walton Journal: Pilot Feasibility Stud Date: 2015-08-25