Literature DB >> 2495184

CD8+ T lymphocyte control of HIV replication in cultured CD4+ cells varies among infected individuals.

C M Walker1, D J Moody, D P Stites, J A Levy.   

Abstract

Production of the human immunodeficiency virus (HIV) by cultured peripheral blood mononuclear cells (PMC) from many seropositive individuals is inhibited by the presence of CD8+ T lymphocytes. In a study of 10 subjects, high levels of virus replication could be detected in cultures of purified CD4+ cells, but not in unseparated PMC. Addition of highly purified, autologous CD8+ cells to the enriched CD4+ cells resulted in a dose-dependent inhibition of HIV growth and revealed that for some individuals, even low numbers of CD8+ cells can prevent replication of the virus. The data also indicated that culturing enriched CD4+ cells could greatly enhance detection of infectious virus in blood specimens and demonstrated that the CD4+ molecule is expressed on infected T cells isolated directly from the peripheral blood.

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Year:  1989        PMID： 2495184     DOI： 10.1016/0008-8749(89)90259-1

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  28 in total

1.  Can repeated plasma donation by asymptomatic HIV-infected individuals delay the onset of AIDS?

Authors:  D R Bainbridge; M W Lowdell; I M Hannet; K W Strauss; A Karpas
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1997-07-29       Impact factor: 6.237

2.  CD8 T lymphocyte subset markers and HIV infection.

Authors:  A G Bird; K C Watret
Journal:  Clin Exp Immunol       Date:  1992-12       Impact factor: 4.330

3.  CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

Authors:  C E Mackewicz; H W Ortega; J A Levy
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

4.  Isolation from African Sykes' monkeys (Cercopithecus mitis) of a lentivirus related to human and simian immunodeficiency viruses.

Authors:  P Emau; H M McClure; M Isahakia; J G Else; P N Fultz
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

Review 5.  The CD8+ T Cell Noncytotoxic Antiviral Responses.

Authors:  Maelig G Morvan; Fernando C Teque; Christopher P Locher; Jay A Levy
Journal:  Microbiol Mol Biol Rev       Date:  2021-05-12       Impact factor: 11.056

6.  Inhibition of HIV replication by CD8+ T cells correlates with CD4 counts and clinical stage of disease.

Authors:  A M Gómez; F M Smaill; K L Rosenthal
Journal:  Clin Exp Immunol       Date:  1994-07       Impact factor: 4.330

Review 7.  Chemokine receptors and chemokines in HIV infection.

Authors:  A Garzino-Demo; A L DeVico; R C Gallo
Journal:  J Clin Immunol       Date:  1998-07       Impact factor: 8.317

8.  Infection of primary CD4+ and CD8+ T lymphocytes by Epstein-Barr virus enhances human immunodeficiency virus expression.

Authors:  M Guan; R D Zhang; B Wu; E E Henderson
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

9.  CD8+ cell anti-HIV activity rapidly increases upon discontinuation of early antiretroviral therapy.

Authors:  M Scott Killian; Jeremy Roop; Sharon Ng; Frederick M Hecht; Jay A Levy
Journal:  J Clin Immunol       Date:  2009-02-03       Impact factor: 8.317

10.  Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism.

Authors:  C M Walker; A L Erickson; F C Hsueh; J A Levy
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103
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