Literature DB >> 24950478

Mixed valence copper(I,II) binuclear complexes with unexpected structure: synthesis, biological properties and anticancer activity.

Alexander G Majouga1, Maria I Zvereva, Maria P Rubtsova, Dmitry A Skvortsov, Andrei V Mironov, Dulat M Azhibek, Olga O Krasnovskaya, Vasily M Gerasimov, Anna V Udina, Nikolay I Vorozhtsov, Elena K Beloglazkina, Leonid Agron, Larisa V Mikhina, Alla V Tretyakova, Nikolay V Zyk, Nikolay S Zefirov, Alexander V Kabanov, Olga A Dontsova.   

Abstract

We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.

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Year:  2014        PMID： 24950478     DOI： 10.1021/jm500154f

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  In vitro and in vivo anti-proliferative evaluation of bis(4'-(4-tolyl)-2,2':6',2″-terpyridine)copper(II) complex against Ehrlich ascites carcinoma tumors.

Authors:  Dharmasivam Mahendiran; Raju Senthil Kumar; Vijayan Viswanathan; Devadasan Velmurugan; Aziz Kalilur Rahiman
Journal:  J Biol Inorg Chem       Date:  2017-09-07       Impact factor: 3.358

2.  Copper coordination compounds with (5Z,5Z')-2,2'-(alkane-α,ω-diyldiselenyl)-bis-5-(2-pyridylmethylene)-3,5-dihydro-4H-imidazol-4-ones. Comparison with sulfur analogue.

Authors:  Alexander V Finko; Anatolii I Sokolov; Dmitry A Guk; Victor A Tafeenko; Anna A Moiseeva; Dmitry A Skvortsov; Andrei A Stomakhin; Andrei A Beloglazkin; Roman S Borisov; Vladimir I Pergushov; Mikhail Ya Melnikov; Nikolay V Zyk; Alexander G Majouga; Elena K Beloglazkina
Journal:  RSC Adv       Date:  2022-03-02       Impact factor: 3.361

Review 3.  Copper Coordination Compounds as Biologically Active Agents.

Authors:  Olga Krasnovskaya; Alexey Naumov; Dmitry Guk; Peter Gorelkin; Alexander Erofeev; Elena Beloglazkina; Alexander Majouga
Journal:  Int J Mol Sci       Date:  2020-05-31       Impact factor: 5.923

4.  Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line.

Authors:  Lilya U Dzhemileva; Vladimir A D'yakonov; Leisan K Dil'mukhametova; Usein M Dzhemilev
Journal:  ACS Omega       Date:  2019-10-11
  4 in total

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