Literature DB >> 2494990

Nitroreductase activity of NADH dehydrogenase of the respiratory redox chain.

G E Smyth1, B A Orsi.   

Abstract

1. An NADH-dependent nitroreductase from the inner membrane of ox liver mitochondria copurified with Complex I of the respiratory redox chain (NADH:ubiquinone oxidoreductase, EC 1.6.5.3). 2. The corresponding nitroreductase from ox heart mitochondria co-purified with the NADH-cytochrome c reductase of Mahler, Sarkar & Vernon [(1952) J. Biol. Chem. 199, 585-597] [NADH: (acceptor) oxidoreductase, EC 1.6.99.3], a component of Complex I that contains the FMN. 3. The mitochondrial nitroreductase activity is attributed to the flavoprotein component of Complex I.

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Year:  1989        PMID： 2494990      PMCID： PMC1135667          DOI： 10.1042/bj2570859

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors:  C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal:  Biochem J       Date:  1955-08       Impact factor: 3.857

2.  Reduction of nitrofuran derivatives by xanthine oxidase and microsomes. Isolation and identification of reduction products.

Authors:  K Tatsumi; S Kitamura; H Yoshimura
Journal:  Arch Biochem Biophys       Date:  1976-07       Impact factor: 4.013

3.  A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.

Authors:  M A Markwell; S M Haas; L L Bieber; N E Tolbert
Journal:  Anal Biochem       Date:  1978-06-15       Impact factor: 3.365

4.  Purification, properties and reconstitutive activity of a DPHN dehydrogenase.

Authors:  R F Baugh; T E King
Journal:  Biochem Biophys Res Commun       Date:  1972-12-04       Impact factor: 3.575

Review 5.  Bioreduction of organic nitrogen.

Authors:  M Mitchard
Journal:  Xenobiotica       Date:  1971 Jul-Oct       Impact factor: 1.908

6.  Preparation and properties of NADH: ubiquinone oxidoreductase (complexI), EC 1.6.5.3.

Authors:  Y Hatefi
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

7.  Nitroreductase activity of mammalian liver aldehyde oxidase.

Authors:  M K Wolpert; J R Althaus; D G Johns
Journal:  J Pharmacol Exp Ther       Date:  1973-05       Impact factor: 4.030

8.  Antigenic and enzymatic architecture of Micrococcus lysodeikticus membranes established by crossed immunoelectrophoresis.

Authors:  P Owen; M R Salton
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

9.  Characteristics of nitro reduction of the carcinogenic agent, 4-nitroINOLONE N-oxide.

Authors:  R Kato; A Takahashi; T Oshima
Journal:  Biochem Pharmacol       Date:  1970-01       Impact factor: 5.858

10.  An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.

Authors:  G L Sottocasa; B Kuylenstierna; L Ernster; A Bergstrand
Journal:  J Cell Biol       Date:  1967-02       Impact factor: 10.539
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