Literature DB >> 2494988

Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187.

W Chao1, A Siafaka-Kapadai, M S Olson, D J Hanahan.   

Abstract

Cultured rat Kupffer cells synthesize and release platelet-activating factor (PAF) when stimulated with calcium ionophore A23187. The production of PAF is concentration- and time-dependent and, based upon [3H]serotonin release assays, approx. 1.0 pmol of PAF is formed per 8 x 10(6) cells during 10 min of ionophore stimulation. It is suggested that Kupffer cells are important cellular components which produce and release PAF in order to facilitate communication between hepatic sinusoidal and parenchymal cells. Further, it is suggested that such mediator production in response to reticulo-endothelial cell stimulation causes the hepatic glycogenolytic response previously in the isolated perfused rat liver.

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Year:  1989        PMID： 2494988      PMCID： PMC1135662          DOI： 10.1042/bj2570823

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  36 in total

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Authors:  E G BLIGH; W J DYER
Journal:  Can J Biochem Physiol       Date:  1959-08

2.  Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation.

Authors:  D L Knook; E C Sleyster
Journal:  Exp Cell Res       Date:  1976-05       Impact factor: 3.905

3.  Release of platelet-activating factor by peritoneal and alveolar macrophages.

Authors:  J Benveniste
Journal:  Monogr Allergy       Date:  1979

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Authors:  R P Siraganian; A G Osler
Journal:  J Immunol       Date:  1971-05       Impact factor: 5.422

5.  Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.

Authors:  R N Pinckard; R S Farr; D J Hanahan
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

6.  Basophil-derived platelet-activating factor (PAF) as an in vivo mediator of acute allergic reactions: demonstration of specific desensitization of platelets to PAF during IgE-induced anaphylaxis in the rabbit.

Authors:  P M Henson; R N Pinckard
Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

7.  Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors:  C A Demopoulos; R N Pinckard; D J Hanahan
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

8.  IgE-induced release of a platelet-activating factor from rabbit lung.

Authors:  T C Kravis; P M Henson
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

9.  The release of four mediators of immediate hypersensitivity from human leukemic basophils.

Authors:  R A Lewis; E J Goetzl; S I Wasserman; F H Valone; R H Rubin; K F Austen
Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422

10.  Release of platelet-activating factor and histamine. I. Effect of immune complexes, complement and neutrophils on human and rabbit mastocytes and basophils.

Authors:  G Camussi; J M Mencia-Huerta; J Benveniste
Journal:  Immunology       Date:  1977-10       Impact factor: 7.397
View more
  9 in total

Review 1.  PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Authors:  M Koltai; D Hosford; P Guinot; A Esanu; P Braquet
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

2.  Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells.

Authors:  T Dohi; K Morita; S Kitayama; A Tsujimoto
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

3.  Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury.

Authors:  Y Komatsu; Y Shiratori; Y Hikiba; N Hashimoto; K Han; T Kawase; H Yoshida; K Okano; M Omata
Journal:  Dig Dis Sci       Date:  1996-05       Impact factor: 3.199

Review 4.  Platelet-activating factor: receptors and signal transduction.

Authors:  W Chao; M S Olson
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

5.  Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma.

Authors:  Muriel Mathonnet; Bernard Descottes; Denis Valleix; Véronique Truffinet; Francois Labrousse; Yves Denizot
Journal:  World J Gastroenterol       Date:  2006-05-07       Impact factor: 5.742

6.  Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.

Authors:  W G Zhou; W Chao; B A Levine; M S Olson
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

7.  Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor.

Authors:  Zhili Xu; Jeffrey S Smith; Jie Tian; Andrew P Byrnes
Journal:  Mol Ther       Date:  2009-12-01       Impact factor: 11.454

8.  Metabolism of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by cultured rat Kupffer cells.

Authors:  W Chao; A Siafaka-Kapadai; D J Hanahan; M S Olson
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857

9.  Fructose-1,6-Bisphosphate inhibits excess activation of Kupffer cell function induced by endotoxin.

Authors:  Takuya Tamaki; Takehiro Nakai; Hiroki Yamaue
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199
  9 in total

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