Jean Woo1, Jason Leung2, John E Morley3. 1. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address: jeanwoowong@cuhk.edu.hk. 2. The Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong. 3. Divisions of Geriatric Medicine and Endocrinology, Saint Louis University School of Medicine, St. Louis, MO.
Abstract
OBJECTIVES: Using data from the Hong Kong Mr and Ms Os study, we validated the SARC-F against 3 consensus definitions of sarcopenia from Europe, Asia, and an international group, and compared the ability of all 4 measures to predict 4-year physical limitation, walking speed, and repeated chair stands. DESIGN: Prospective cohort study. SETTING: Hong Kong community. PARTICIPANTS: Four thousand men and women living in the community. MEASUREMENTS: A questionnaire regarding ability to carry a heavy load, walking, rising from a chair, climbing stairs, and falls frequency was administered. These questions were used to calculate the SARC-F score. Measurements, including appendicular muscle mass, were taken using dual-energy X-ray, grip strength using a dynamometer, 6-m gait speed, and time taken for repeated chair stand. Classification using the SARC-F score was compared using consensus panel criteria from international, European, and Asian sarcopenia working groups. The performance of all 4 methods was compared by examining the predictive ability for 4-year outcomes using ROC curve. RESULTS: The SARC-F has excellent specificity but poor sensitivity for sarcopenia classification; however, all 4 methods have comparable but modest predictive power for 4-year physical limitation. CONCLUSION: The SARC-F may be considered a suitable tool for community screening for sarcopenia.
OBJECTIVES: Using data from the Hong Kong Mr and Ms Os study, we validated the SARC-F against 3 consensus definitions of sarcopenia from Europe, Asia, and an international group, and compared the ability of all 4 measures to predict 4-year physical limitation, walking speed, and repeated chair stands. DESIGN: Prospective cohort study. SETTING: Hong Kong community. PARTICIPANTS: Four thousand men and women living in the community. MEASUREMENTS: A questionnaire regarding ability to carry a heavy load, walking, rising from a chair, climbing stairs, and falls frequency was administered. These questions were used to calculate the SARC-F score. Measurements, including appendicular muscle mass, were taken using dual-energy X-ray, grip strength using a dynamometer, 6-m gait speed, and time taken for repeated chair stand. Classification using the SARC-F score was compared using consensus panel criteria from international, European, and Asian sarcopenia working groups. The performance of all 4 methods was compared by examining the predictive ability for 4-year outcomes using ROC curve. RESULTS: The SARC-F has excellent specificity but poor sensitivity for sarcopenia classification; however, all 4 methods have comparable but modest predictive power for 4-year physical limitation. CONCLUSION: The SARC-F may be considered a suitable tool for community screening for sarcopenia.
Authors: Stephan von Haehling; Nicole Ebner; Marcelo R Dos Santos; Jochen Springer; Stefan D Anker Journal: Nat Rev Cardiol Date: 2017-04-24 Impact factor: 32.419