Enver Zerem1, Safet Omerovic, Suad Kunosic. 1. Department of Medical Sciences, The Academy of Sciences and Arts of Bosnia and Herzegovina, University Clinical Center Tuzla, Bistrik 7, Sarajevo, Bosnia and Herzegovina.
Abstract
BACKGROUND: The management of liver abscess (LA) has shifted toward intravenous broad-spectrum antibiotics and image-guided percutaneous needle aspiration (PNA) or percutaneous catheter drainage (PCD). AIM: To evaluate the efficacy of percutaneous treatment for patients with LA. METHODS: We performed a retrospective analysis of 264 patients with 354 LA treated by percutaneous management from 1989 to 2012. All patients received appropriate antibiotic therapy. Patients with LA <50 mm in diameter were initially treated by sonographic-guided PNA and those with LA ≥50 mm were initially treated by ultrasound ultrasound-guided PCD. Surgery was planned only when there was no clinical improvement after the initial nonsurgical treatment. Primary outcome was the conversion rate to surgery. Secondary outcomes were mortality, length of hospital stay, and the procedure-related complications. RESULTS: PNA was performed initially in 116 patients (44%), with 70 of them later requiring PCD due to abscess recurrence. In 148 patients (56%), PCD was performed initially. PCD was performed twice or more in 63 patients. Percutaneous treatment was the definitive and successful treatment in 230 of 264 patients (87.1%). Twenty patients (7.7%) were converted to surgery. Twenty-one patients (7.9%) died. The median hospital stay was 12 (range, 9-18) days, with complications occurring in 23 patients (8.7%). CONCLUSIONS: Percutaneous management with systemic antibiotics is effective and safe and allows resolution of most LA. However, a small proportion of patients with LA still requires surgical drainage.
BACKGROUND: The management of liver abscess (LA) has shifted toward intravenous broad-spectrum antibiotics and image-guided percutaneous needle aspiration (PNA) or percutaneous catheter drainage (PCD). AIM: To evaluate the efficacy of percutaneous treatment for patients with LA. METHODS: We performed a retrospective analysis of 264 patients with 354 LA treated by percutaneous management from 1989 to 2012. All patients received appropriate antibiotic therapy. Patients with LA <50 mm in diameter were initially treated by sonographic-guided PNA and those with LA ≥50 mm were initially treated by ultrasound ultrasound-guided PCD. Surgery was planned only when there was no clinical improvement after the initial nonsurgical treatment. Primary outcome was the conversion rate to surgery. Secondary outcomes were mortality, length of hospital stay, and the procedure-related complications. RESULTS: PNA was performed initially in 116 patients (44%), with 70 of them later requiring PCD due to abscess recurrence. In 148 patients (56%), PCD was performed initially. PCD was performed twice or more in 63 patients. Percutaneous treatment was the definitive and successful treatment in 230 of 264 patients (87.1%). Twenty patients (7.7%) were converted to surgery. Twenty-one patients (7.9%) died. The median hospital stay was 12 (range, 9-18) days, with complications occurring in 23 patients (8.7%). CONCLUSIONS: Percutaneous management with systemic antibiotics is effective and safe and allows resolution of most LA. However, a small proportion of patients with LA still requires surgical drainage.
Authors: Christian D Klink; Marcel Binnebösel; Maximilian Schmeding; Ronald M van Dam; Cornelis H Dejong; Karsten Junge; Ulf P Neumann Journal: HPB (Oxford) Date: 2015-06-12 Impact factor: 3.647