Gianluca Rossetti1, Paolo Limongelli2, Marco Cimmino3, Domenico Napoletano4, Maria Chiara Bondanese5, Giovanni Romano6, Manousos Pratilas7, Ludovica Guerriero8, Francesco Orlando9, Giovanni Conzo10, Bruno Amato11, Giovanni Docimo12, Salvatore Tolone13, Luigi Brusciano14, Ludovico Docimo15, Landino Fei16. 1. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: gianlucarossetti@yahoo.it. 2. Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy. Electronic address: limpao@libero.it. 3. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: drmarcocimmino@gmail.com. 4. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: dom.napoletano@gmail.com. 5. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: mariachiarabondanese@libero.it. 6. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: giovanniromano14@virgilio.it. 7. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: pratilasmanos@hotmail.com. 8. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: ludovica.guerriero@gmail.com. 9. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: francesco.orlando1@gmail.com. 10. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: giovanni.conzo@unina2.it. 11. Department of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico II, Italy. Electronic address: bruno.amato@unina.it. 12. Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy. Electronic address: giovanni.docimo@unina2.it. 13. Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy. Electronic address: salvatore.tolone@tin.it. 14. Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy. Electronic address: luigibrusciano@tin.it. 15. Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy. Electronic address: ludovico.docimo@unina2.it. 16. Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. Electronic address: landino.fei@tin.it.
Abstract
INTRODUCTION: Aim of this study is to determine whether quality of life (QoL) assessment in association with instrumental evaluation can help to identify factors predictive of outcome both in surgically and medically treated GERD patients. METHODS: Between January 2005 and June 2010, 301 patients affected with GERD were included in the study. QoL was evaluated by means of GERD-HRQL and SF-36 questionnaires administered before treatment, at 6 months, at 1 year follow-up and at the end of the study. The multivariate analysis was used to detect if variables such as sex, age, heartburn, acid regurgitation, dysphagia, presence of esophagitis, percentage of total time at pH < 4, symptom index score (SI), the SF-36 and HRQL scores before treatment, at 6 months and 1 year could affect the QoL questionnaires scores at the end of the study. RESULTS: One hundred forty-seven patients were included in the surgical group and 154 in the medical group. No differences with regard to gender, age, mean SF-36 and HRQL scores before treatment were documented. At the end of the study, quality of life was significantly improved for SF-36 and HRQL scores, either for surgical or medical group. The multivariate analysis showed no factors individually affected the SF-36 and the HRQL scores, but symptom index score (SI) and QoL questionnaires scores at 6 months and 1 year follow-up. CONCLUSIONS: The combined use of pHmetry with evaluation of SI and QoL questionnaires can predict the outcome of GERD patients managed either by medical or surgical therapy.
INTRODUCTION: Aim of this study is to determine whether quality of life (QoL) assessment in association with instrumental evaluation can help to identify factors predictive of outcome both in surgically and medically treated GERDpatients. METHODS: Between January 2005 and June 2010, 301 patients affected with GERD were included in the study. QoL was evaluated by means of GERD-HRQL and SF-36 questionnaires administered before treatment, at 6 months, at 1 year follow-up and at the end of the study. The multivariate analysis was used to detect if variables such as sex, age, heartburn, acid regurgitation, dysphagia, presence of esophagitis, percentage of total time at pH < 4, symptom index score (SI), the SF-36 and HRQL scores before treatment, at 6 months and 1 year could affect the QoL questionnaires scores at the end of the study. RESULTS: One hundred forty-seven patients were included in the surgical group and 154 in the medical group. No differences with regard to gender, age, mean SF-36 and HRQL scores before treatment were documented. At the end of the study, quality of life was significantly improved for SF-36 and HRQL scores, either for surgical or medical group. The multivariate analysis showed no factors individually affected the SF-36 and the HRQL scores, but symptom index score (SI) and QoL questionnaires scores at 6 months and 1 year follow-up. CONCLUSIONS: The combined use of pHmetry with evaluation of SI and QoL questionnaires can predict the outcome of GERDpatients managed either by medical or surgical therapy.
Authors: Maureen Moore; Cheguevara Afaneh; Daniel Benhuri; Caroline Antonacci; Jonathan Abelson; Rasa Zarnegar Journal: World J Gastrointest Surg Date: 2016-01-27
Authors: Mikhail Attaar; Bailey Su; Harry Wong; Zachary Callahan; Kristine Kuchta; Stephen Stearns; John G Linn; Woody Denham; Stephen P Haggerty; Michael B Ujiki Journal: Surg Endosc Date: 2021-08-31 Impact factor: 3.453