| Literature DB >> 24946158 |
Yuanyan Liu1, Zhenli Liu2, Cheng Lu3, Jianbei Li4, Zhangchi Ning5, Zhiqian Song6, Chun Wang6, Zhiyong Du6, Xinmiao Lu7, Siyu Zhao7, Aiping Lu8.
Abstract
Frankincense resins are extensively used as natural remedies in regions ranging from North Africa to China. Triterpenoid metabolites from frankincense exhibit notable anti-inflammatory and anti-tumor properties. In the present paper, without the use of an isolation process, the fragmentation rules and NMR spectral characteristics of triterpenoid metabolites in frankincense are summarized through a coupling method using high performance liquid chromatography-diode array detection/electrospray ionization tandem mass spectrometry (HPLC-DAD/ESI-MS(n)) combined with HPLC-nuclear magnetic resonance (NMR) experiments. Based on this groundwork, a coupling strategy for the comprehensive metabolic profiling of active triterpenoid metabolites from enriched fractions of frankincense was developed. The proposed strategy may serve as a method for the holistic screening of bioactive metabolites in complex TCM samples.Entities:
Keywords: Frankincense resins; Mass spectrometry; Metabolic profiling; Nuclear magnetic resonance; Triterpenoid metabolites
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Year: 2014 PMID： 24946158 DOI： 10.1016/j.jchromb.2014.05.054
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN： 1570-0232 Impact factor: 3.205