Pierre Senesse1, Abir Tadmouri2, Stéphane Culine3, Patrick R Dufour4, Patrick Seys5, Abderraouf Radji6, Maciej Rotarski7, Axel Balian8, Cecile Chambrier9. 1. SIRIC Montpellier Cancer, Institut régional du Cancer de Montpellier (ICM), Montpellier, France; Laboratory Epsylon, EA 4556 Dynamics of Human Abilities & Health Behaviors, University of Montpellier, Montpellier, France; Department of Clinical Nutrition and Gastroenterology, ICM, Montpellier, France. Electronic address: pierre.senesse@icm.unicancer.fr. 2. Scientific Department, ClinSearch, Bagneux, France. 3. Department of Oncology, Hospital Henri Mondor, Créteil, France. 4. Centre de Lutte Contre Cancer, Centre Paul Strauss, Strasbourg, France. 5. Department of Oncology, Polyclinique de Blois, Blois, France. 6. Department of Oncology, Centre Frédéric Joliot, Rouen, France. 7. Department of Oncology, Radiation Oncology Centre, Bayonne, France. 8. Department of Hepatogastroenterology, Hospital Antoine Béclère, Clarmart, France. 9. Clinical Nutrition Intensive Care Unit, Hospices Civils de Lyon, Lyon, France.
Abstract
CONTEXT: Patients with gastrointestinal cancer are at high risk for deterioration of nutrition. Home parenteral nutrition (HPN) could improve nutritional status and quality of life (QoL). OBJECTIVES: The purpose of this study was 1) to evaluate the impact of HPN on QoL, 2) to assess changes in nutritional status, and 3) to assess proxy perception of patient well-being. METHODS: We conducted a prospective, observational, and a multicenter study. Inclusion criteria were adult patients with gastrointestinal cancer, for whom HPN was indicated and prescribed for at least 14 days. The physician, the patient, and a family member completed questionnaires at inclusion and 28 days later. The QoL was assessed by the patients using the Functional Assessment of Cancer Therapy-General questionnaire, at inclusion and 28 days later. RESULTS: The study included 370 patients with gastrointestinal cancer. The HPN was indicated for cancer-related undernutrition in 89% of the patients and was used as a complement to oral intake in 84%. After 28 days of parenteral intake, global QoL was significantly increased (48.9 at inclusion vs. 50.3, P=0.007). The patients' weight improved significantly by 2.7% (P<0.001). The nutrition risk screening also decreased significantly (3.2±1.1 vs. 2.8±1.3, P=0.003). CONCLUSION: HPN could provide benefit for malnourished patients with gastrointestinal cancer. However, randomized controlled studies are required to confirm this benefit and the safety profile.
CONTEXT: Patients with gastrointestinal cancer are at high risk for deterioration of nutrition. Home parenteral nutrition (HPN) could improve nutritional status and quality of life (QoL). OBJECTIVES: The purpose of this study was 1) to evaluate the impact of HPN on QoL, 2) to assess changes in nutritional status, and 3) to assess proxy perception of patient well-being. METHODS: We conducted a prospective, observational, and a multicenter study. Inclusion criteria were adult patients with gastrointestinal cancer, for whom HPN was indicated and prescribed for at least 14 days. The physician, the patient, and a family member completed questionnaires at inclusion and 28 days later. The QoL was assessed by the patients using the Functional Assessment of Cancer Therapy-General questionnaire, at inclusion and 28 days later. RESULTS: The study included 370 patients with gastrointestinal cancer. The HPN was indicated for cancer-related undernutrition in 89% of the patients and was used as a complement to oral intake in 84%. After 28 days of parenteral intake, global QoL was significantly increased (48.9 at inclusion vs. 50.3, P=0.007). The patients' weight improved significantly by 2.7% (P<0.001). The nutrition risk screening also decreased significantly (3.2±1.1 vs. 2.8±1.3, P=0.003). CONCLUSION: HPN could provide benefit for malnourished patients with gastrointestinal cancer. However, randomized controlled studies are required to confirm this benefit and the safety profile.
Authors: M Durán-Poveda; P Jimenez-Fonseca; M Sirvent-Ochando; P P García-Luna; J L Pereira-Cunill; B Lema-Marqués; M T Parejo-Arrondo; C Belda-Iniesta Journal: Clin Transl Oncol Date: 2018-03-02 Impact factor: 3.405
Authors: Maria Ines Pinto-Sanchez; Shannon Gadowsky; Suzan McKenzie; Michael J Raphael; Anne Childs; Marroon Thabane; Suzanne Hansen; John K Marshall; David Armstrong Journal: J Can Assoc Gastroenterol Date: 2018-08-10