The relationships of self-efficacy, physical activity, and paid work to health-related quality of life among patients with chronic obstructive pulmonary disease (COPD).

PURPOSE: Although chronic obstructive pulmonary disease (COPD) primarily affects the lungs, it is regarded as a systemic disorder associated with comorbidity and physical deterioration, which often results in reduced levels of health-related quality of life (HRQoL). Self-efficacy is an important concept in self-management, which is vital for improving HRQoL in patients with COPD. The purpose of this study was to examine how general self-efficacy, leisure time physical activity, and sociodemographic variables such as employment status are related to the physical and mental health components of HRQoL in patients with COPD. PATIENTS AND METHODS: In this cross-sectional study, 97 COPD patients (54.6% male, mean age 64.6 years, standard deviation [SD] 9.5) beginning a pulmonary rehabilitation program completed three self-report questionnaires: the short form (SF)-12v2 Health Survey as a measure of HRQoL; the General Self-Efficacy Scale; and a standardized instrument measuring regular leisure time physical activity.
RESULTS: The physical health component median score was 31.3 (interquartile range [IQR] 16.3) and the mental health component median score was 45.9 (IQR 21.5). Two sets of linear regression analyses were performed, one predicting physical health and the other predicting mental health. The first analysis showed that better physical health was directly related to being in paid work (P-value <0.001), but was not significantly related to age, sex, marital status, education, work status, physical activity, or self-efficacy. In the second analysis, better mental health was directly related to living with a partner, being physically active, and having higher self-efficacy (P-value <0.001).
CONCLUSION: The findings suggest that general self-efficacy has differential relationships to the two dimensions of HRQoL. Our results indicate that general self-efficacy, physical activity, and paid work might be important factors for improving HRQoL of persons with COPD, and should be taken into consideration in pulmonary rehabilitation.

Introduction

According to estimates of the World Health Organization, 65 million people have moderate to severe chronic obstructive pulmonary disease (COPD).1 In 2002, COPD was the fifth leading cause of death, and it is estimated that by 2030 it will become the third leading cause of death, worldwide.1 Although COPD primarily affects the lungs, it is regarded as a systemic disorder associated with cardiovascular diseases, muscle wasting, and bone loss.2,3 As a result of these changes and even with optimal medical treatment, COPD often results in reduced levels of health-related quality of life (HRQoL).3–5 HRQoL is an established concept in the health sciences, describing aspects of an individual’s subjective evaluation of their health, disease, disability, impairment, and the effectiveness of treatment.6,7

As a supplement to pharmacological therapy, pulmonary rehabilitation (PR) has emerged as a standard of care for patients with COPD.8 In Norway, at a minimum, PR programs include physical training, education, and psychosocial support. Although all PR programs include these components, they may vary considerably in their extent and structure. The principal goals of PR are to reduce symptoms, improve HRQoL, and increase physical and emotional participation in everyday activities.9,10 Physical training and self-efficacy are core components of PR programs available for COPD patients with lower HRQoL.8,9 Physical training may help to reduce muscle deconditioning, which occurs when physical activity is restricted by breathlessness and fatigue, and thus lead to better HRQoL.9,11 Many COPD patients are advised to do daily exercises (eg, walking 20 minutes daily), and observational studies indicate that leisure time physical activity has significant benefits, such as reduced hospital admissions and mortality12 and better HRQoL among patients with COPD.13

Self-management is the individual’s ability to manage symptoms, treatment, physical and psychosocial consequences, and lifestyle changes when living with a chronic condition.14 Self-efficacy is an important construct in self-management9 and refers to the confidence people have in their ability to perform actions that are required to deal with particular situations.15 Self-efficacy is distinct from true or actual capability, but seems to guide health behavior and control disease, resulting in better HRQoL.9,15,16 Many COPD patients seem to lose their sense of control over the disease and their lives, which may lead to lower self-efficacy.16,17 Hence, the expectations COPD patients have for their own self-efficacy are important as they can affect their success in self-management.16 Previous studies have found that, among COPD patients waiting to begin a PR program, those who had higher levels of disease-specific self-efficacy reported better physical, psychological, and social function as well as total health compared with those who had lower levels of self-efficacy.18,19

Although several studies have evaluated HRQoL in patients with COPD, health professionals need to understand the factors that potentially influence HRQoL in persons with COPD in order to better meet the needs of this population. To the authors’ knowledge, no previous studies have evaluated the importance of general self-efficacy for HRQoL among patients with COPD. Thus, the aim of the present study was to evaluate the relationships among physical activity, general self-efficacy, and the physical and mental components of HRQoL, while controlling for selected demographic variables such as age, education, cohabitation, and employment status, in a sample of COPD patients at the start of a PR program.

Material and methods

A prospective longitudinal study was designed to explore whether participation in a patient educational course for persons with COPD or obesity might contribute to changes in HRQoL, and also to examine 12 instruments assessing perception of illness and coping strategies and to evaluate their ability to detect change over time.20 This article reports findings from a cross-sectional correlational analysis of HRQoL, physical activity, self-efficacy, and socio-demographic factors among participants with COPD.

Sampling and procedure

In this convenience sample, patients were recruited in 2009–2010 at six different pulmonary rehabilitation programs in Southern Norway. All 127 participants attending the courses were given verbal and written information about the study and asked to participate on the first day of the PR course. The only inclusion criterion was course attendance. Those who gave their written consent completed the questionnaires and demographic information in a secluded room on-site, and returned the information in a sealed envelope the same day. The project representative collected the envelopes.

Of the 127 individuals asked to participate in the study, 100 (78.7%) consented and 97 persons (97.0%) had complete scores and were included in the analysis. The course participants included in the analysis (n=97) did not differ with respect to age (P=0.24) or sex (P=0.30) from those who were excluded due to incomplete scores or who did not consent (n=30).

Measurements

HRQoL was measured with the short form (SF)-12 Health Survey, version 2 (SF-12v2) with 1-week recall. The 12-item version is a widely used abbreviated questionnaire derived from the Medical Outcomes Study SF-36 instrument and measures eight domains of physical functioning, role limitations due to physical health, bodily pain, general health perceptions, vitality, social functioning, role limitations due to emotional problems, and mental health.21,22 The raw scores on the eight scales are converted to standard scores from 0 (lowest HRQoL) to 100 (highest HRQoL). A physical component summary (PCS) and a mental component summary (MCS) score were computed, reflecting underlying physical and mental dimensions of HRQoL, respectively.21 Norm-based standardized scores, based on the 1998 general US population,21 were computed for all eight scales. Missing items were replaced with the mean of the other items in the same scale. The SF-12 has been validated for use in the USA, UK, and many other European countries.23 The SF-12 has shown excellent measurement properties in COPD populations.24

Level of physical activity (PA) was measured by two items from the Norwegian Nord-Trøndelag Health Survey (HUNT study), assessing frequency and intensity of leisure activities.25 In response to the question “How much physical activity do you have during leisure time?”, participants were asked to state approximately how many hours per week they performed; either: 1) low-level physical activity (not becoming sweaty/breathless); and/or 2) high-level activity (becoming sweaty/breathless). Response alternatives were “no activity”, “less than 1 hour”, “1 to 2 hours”, and “3 or more hours a week”. An index score ranging from 0–3 was computed in accordance with the current published categorization.25 The PA questions from HUNT have been used in a number of studies assessing the possible effects of PA on different health outcomes, including mortality, stroke, diabetes, weight control, risk of several types of cancer, and osteoporosis.26,27 Acceptable test-retest reliability and acceptable validity, particularly for measurement of moderate and high-intensity leisure PA, have been reported.26

Self-efficacy was assessed using the General Self-Efficacy Scale (GSE).28 The GSE is a ten-item scale designed to evaluate the beliefs that one can perform novel or difficult tasks in life or cope with hardship (eg, “I am confident that I could deal efficiently with unexpected events”). The score for each question ranges from 1 to 4, with the anchors “completely disagree” and “completely agree”. A GSE score is calculated by summing the responses to all ten items; higher scores indicate stronger self-efficacy (range from ten to 40). Up to two of the responses (20%) were allowed to be missing and were replaced with the mean value of the person’s valid scores. The scale has been translated into several languages, including Norwegian, and has demonstrated good psychometric properties.28–30 In the present study, the internal reliability coefficient for the scale was 0.92, which is considered excellent.6

Data were also collected on age (years), sex, marital status (married/cohabitating versus not married/not cohabitating), and employment status (in paid work versus not in paid work). Respondents were asked to indicate their highest formal education. Response categories were primary school education (7–9 years), 1 or 2 years of secondary school (10–11 years), 3 years of secondary school (12 years), lower university (13–15 years), and higher university (≥16 years). Formal education was dichotomized into two categories: up to 12 years education versus more than 12 years.

Ethics

The Regional Medical Research Ethics Committee of Norway (REK S-08662c 2008/17575), and the Ombudsman of Oslo University Hospital approved the study. Informed written consent was obtained from all participants.

Statistical analysis

Normality of the data was assessed by visual inspection, and several of the HRQoL scales were not normally distributed. Independent t-tests (for two samples with equal or unequal variance when appropriate) were used to analyze continuous variables with normal distributions (age, physical activity, and GSE), and the non-parametric Mann–Whitney U test was used for the HRQoL scales. Ordinal and categorical data were analyzed using the chi-square and the Fisher’s exact tests. Pearson’s correlation coefficient (r) was used for correlation analysis. Descriptive statistics included mean scores with standard deviation or median scores with interquartile range. Cronbach’s α was computed to assess the internal consistency of the scales.31

To determine the relationship between the independent variables and HRQoL, two sets of linear regression analyses were performed. The PCS score was used as the dependent variable in the first set of analyses and the MCS score as the dependent variable in the second. First, selected variables were analyzed using a univariate linear regression model. Next, variables that were statistically significant, as well as age and sex, were fit into a multiple variable model. The following independent variables were evaluated in the analyses: sociodemographic variables (age, sex, marital status, education, and work status); physical activity; and self-efficacy. Because all bivariate correlations between variables used in the analysis were r<0.7, we assumed no multicollinearity of variables. The model fit was assessed by inspection of the residuals. Transformation of the non-normal data was considered, but, since it did not alter the findings and the residuals indicated good model fit, parametric linear regression using untransformed data was determined to be an acceptable statistical approach for analyzing both PCS and MCS scores. The results are presented as estimates of beta with 95% confidence intervals and P-values. The level of significance was set at P<0.05 and all tests were two-tailed. Cohen’s d was used to calculate effect size, and d≥0.4 was defined as clinically significant.32,33 Data were analyzed using SPSS for Windows version 18.0 (IBM Corporation, Armonk, NY, USA).

Results

Sample characteristics

The sociodemographic characteristics of the sample are presented in Table 1. Mean age was 64.6 years (standard deviation =9.5) and ranged from 38 to 85 years. There were no statistically significant demographic differences between the men and women in this sample.

Table 1

Sociodemographic characteristics of the study sample

	Alln=97 (100%)	Menn=53 (54.6%)	Womenn=44 (45.4%)	t	P-value
	Mean (SD)	Mean (SD)	Mean (SD)
Age (years): mean (SD)	64.6 (9.5)n (%)	65.1 (10.0)n (%)	64.0 (8.9)n (%)	0.584χ2 (df)	0.561P-value
Level of formal education				0.013 (1)	0.910
Up to 12 years	70 (72.2)	38 (71.7)	32 (72.7)
13 years or more	27 (27.8)	14 (27.5)	12 (29.3)
Partner status				2.641 (1)	0.104
Married/cohabitating	55 (56.7)	34 (64.2)	21 (47.7)
Employment status				0.176 (1)	0.675
Paid work	24 (24.7)	14 (26.4)	10 (22.7)

Note: P-values reflect comparisons of men and women by Student’s t-test or chi-square test.

Abbreviations: SD, standard deviation; df, degrees of freedom.

The median scores of the study variables in relation to sex are shown in Table 2. Men scored higher than women on four of the SF-12v2 scales: bodily pain (P=0.02, d=0.53); vitality (P=0.02, d=46); role limitations due to emotional problems (P=0.004, d=0.57); and mental health (P=0.03, d=0.48). Men also scored higher on the aggregated mental health component of the SF-12v2 (P=0.03, d=0.47). No other sex differences were detected.

Table 2

Physical activity, self-efficacy (GSE), and HRQoL (SF-12v2) scores among men and women

Variables	Scales	Alln=97	Menn=53	Womenn=44	P-value	Effect size
		Median [IQR]	Median [IQR]	Median [IQR]		d
Physical activity	0–3	1.00 [1.50]	1.00 [2.00]	1.00 [1.00]	0.264	0.21
Self-efficacy	1–40	26.00 [11.00]	27.00 [10.50]	25.50 [10.50]	0.235	0.24
HRQoL scales
Physical functioning	0–100	25.00 [50.00]	25.00 [50.00]	25.00 [50.00]	0.154	0.28
Role physical	0–100	37.50 [37.50]	50.00 [50.00]	37.50 [46.88]	0.097	0.19
Bodily pain	0–100	75.00 [75.00]	75.00 [50.00]	50.00 [50.00]	0.016a	0.53
General health	0–100	25.00 [47.50]	25.00 [47.50]	25.00 [45.00]	0.190	0.30
Vitality	0–100	25.00 [50.00]	25.00 [25.00]	25.00 [25.00]	0.015a	0.46
Social functioning	0–100	75.00 [75.00]	75.00 [62.50]	75.00 [68.75]	0.302	0.21
Role emotional	0–100	75.00 [62.50]	87.00 [37.50]	56.25 [62.50]	0.004a	0.57
Mental health	0–100	62.50 [37.50]	75.00 [37.50]	62.50 [25.00]	0.028a	0.48
HRQoL components
Physical health	0–100	31.25 [16.3]	34.52 [17.42]	29.62 [17.19]	0.156	0.29
Mental health	0–100	45.89 [21.5]	53.42 [18.51]	43.41 [20.50]	0.026a	0.47

Notes: Data are study median values and interquartile range. P-values reflect comparisons of men and women by Student’s t-test (physical activity, GSE) and Mann–Whitney U test (HRQoL scales). Higher HRQoL scores indicate better health. The effect size of each comparison is expressed by Cohen’s d. HRQoL measured by the short form (SF)-12v2 Health Survey.

Statistically significant (P<0.05).

Abbreviations: GSE, General Self-Efficacy Scale; HRQoL, health-related quality of life; IQR, interquartile range.

Regression analyses

The linear regression analysis included two sets of models, the first predicting physical health (PCS score) and the second predicting mental (MCS score); the model fit for both was very good (Tables 3 and 4). Univariate analyses from the first set showed that only younger age and being in paid work were related to higher PCS (P=0.018 and P<0.001, respectively). The other sociodemographic variables, physical activity, and self-efficacy were not related to PCS. The final multivariate model explained 17.6% of the variance in PCS, and being in paid work was significantly associated with PCS, even when controlling for age and sex.

Table 3

Univariate and multivariate linear regression analyses predicting HRQoL physical component summary score (n=97)

Variables	Univariate			Multivariate
	B	95% CI	P-value	B	95% CI	P-value
Age	−0.278	−0.508 to −0.049	0.018a	−0.105	−0.350 to 0.139	0.395
Female sex (male as ref)	−3.186	−7.608 to 1.237	0.156	−2.984	−7.105 to 1.138	0.154
Paid work (no paid work as ref)	9.913	5.168 to 14.659	<0.001a	8.714	3.374 to 14.054	<0.001a
Partnered (unpartnered as ref)	−2.235	−6.703 to 2.233	0.323
Education	−0.068	−1.675 to 1.538	0.933
Physical activity	2.004	−0.342 to 4.351	0.093
Self-efficacy	0.299	−0.036 to 0.635	0.080

Note:

Statistically significant (P<0.05).

Abbreviations: B, estimate of beta; CI, confidence interval; HRQoL, health-related quality of life; ref, reference.

Table 4

Univariate and multivariate linear regression analyses predicting HRQoL mental component summary score (n=97)

Variables	Univariate			Multivariate
	B	95% CI	P-value	B	95% CI	P-value
Age	0.115	−0.153 to 0.384	0.396	0.207	−0.012 to 0.426	0.064
Female sex (male as ref)	−5.729	−10.695 to −0.764	0.024a	−2.667	−6.826 to 1.491	0.206
Paid work (no paid work as ref)	−2.125	−7.994 to 3.743	0.474
Partnered (unpartnered as ref)	5.709	0.718 to 10.700	0.025a	4.389	0.194 to 8.585	0.041a
Education	1.200	−0.617 to 3.016	0.193
Physical activity	3.313	0.680 to 5.946	0.014a	2.737	0.473 to 5.000	0.018a
Self-efficacy	1.047	0.721 to 1.372	<0.001a	0.953	0.636 to 1.270	<0.001a

Note:

Statistically significant (P<0.05).

Abbreviations: B, estimate of beta; CI, confidence interval; HRQoL, health-related quality of life; ref, reference.

In the second set of linear regression analyses with MCS as the dependent variable, univariate analyses indicated that being male, living with a partner, having higher levels of physical activity, and having higher self-efficacy were significantly associated with better mental health. Self-efficacy explained 30.0% of the variance in MCS in the univariate analysis. In the multivariate analysis, living with a partner, having higher physical activity, and having higher self-efficacy were significant predictors of MCS, controlling for age and sex. The final multivariate model explained 40.2% of the variance in MCS.

Discussion

The present study indicated that four of the factors examined were significantly associated with HRQoL in adjusted analyses; participation in paid work was associated with higher PCS, while living with a partner, and having higher levels of physical activity, and self-efficacy were associated with higher MCS. Thus, it seems that different factors are related to the physical and mental components of HRQoL. To our knowledge, this is the first study to describe the relationship between general self-efficacy and HRQoL in this population.

Mental health and self-efficacy

Our findings indicate that self-efficacy is an important factor for mental health, explaining 30% of the variance in MCS scores. Previous COPD research has found that a higher level of COPD-specific self-efficacy is associated with less anxiety and depression34 and better mental health.18 The MCS includes items assessing the extent to which emotional symptoms such as anxiety and depression interfered with daily activities.21,22 People often experience anxiety when they feel incapable of managing various daily activities, and the inability to accomplish everyday activities can also contribute to feelings of depression.15 Our finding is thus consistent with Bandura’s theory15 that self-efficacy reflects people’s belief in their ability to manage anxiety and depression and to perform daily activities. Consequently, a feeling of control in managing the emotional consequences of the disease, as well as in managing daily activities, might be essential for mental health among patients with COPD. Self-efficacy has been shown to be a mediator of quality of life in many different populations, including those with rheumatoid arthritis,35 surgery patients,36 and breast cancer survivors.37 It is thus likely that self-efficacy is acting as a mediator between disease and mental health in the COPD population as well.

Physical health and self-efficacy

It is interesting to note that no association was found between general self-efficacy and the PCS, a measure of patients’ physical health and the extent to which they are physically capable of performing day-to-day activities. This finding seems to contradict previous studies reporting associations between COPD-specific measures of self-efficacy in relation to physical health.18,19,38 However, it has been proposed that self-efficacy could be structured hierarchically from task-specific to global self-efficacy,39 and it is possible that specific and general types of self-efficacy have different associations with physical health in this population. Additional research assessing both task- and context-specific self-efficacy as well as general self-efficacy is warranted to better understand their potentially differing relationships to physical and mental health among patients with COPD.

Physical activity

The present study indicated no association between self-reported physical activity and the PCS. The low correlation between physical activity and the PCS may seem somewhat surprising, although two systematic reviews also confirm the absence of a clear relationship between physical activity and quality of life in COPD.40,41 One potential explanation of these findings is that the PCS provides more in-depth evaluation, covering a variety of aspects of life such as functional status, perceptions, and social opportunities,22 ie, not only physical activity. However, higher physical activity was associated with the MCS. This finding is in line with epidemiological studies.42 Furthermore, a large multicenter study of COPD patients indicated that the amount of daily walking time was directly related to better HRQoL and inversely related to lower levels of anxiety and depression.13

Our course participants, who were just beginning a PR program, reported low levels of leisure time physical activity. Despite the indisputable benefit of physical activity, there are several reasons why persons with COPD find this part of self-management difficult. In addition to the deconditioning cycle, some reasons also lie outside the individual’s control, such as variation in their day-to-day condition and exacerbations.8 Our participants scored below the general US population norms21 on several of the SF-12 scales, such as general health, physical functioning, vitality, and role performance because of physical problems, as well as the PCS and MCS components. Our findings are consistent with similar COPD studies, demonstrating that COPD patients at the start of a PR program tend to report low HRQoL.3,43,44 If individuals with COPD, although functionally capable, are not physically active and have low self-efficacy related to physical activity, they may develop a reduced exercise tolerance, become more sedentary, and further compromise their health as they age with the disease. Leisure time physical activity reflects one’s own choice, and motivating people to increased physical activity is central in PR. Longitudinal interventional studies have reported a predictive relationship between improvement in exercise tolerance, disease-specific self-efficacy, and quality of life in patients with COPD attending PR.45

Paid work

Our study revealed that being in paid work was associated with better PCS but not with better MCS among patients with COPD. These findings are comparable to the study of Orbon et al,46 in which working patients scored higher than patients receiving disability benefits on all quality of life domains of the Chronic Respiratory Questionnaire,47 except for the emotions domain. Whether a person is able to remain in paid work is a complex concurrence of many factors, and since working probably demands a reasonably high level of physical health, the causal association between employment status and PCS could function in the reverse direction, with not having a paid job being primarily a consequence of being severely affected with COPD and having poor HRQoL. If so, disease severity could act as a potential confounder of the relationship between employment status and HRQoL. However, previous studies show divergent results regarding the importance of disease severity for work status.46,48 The positive association between paid work and the PCS might cautiously be interpreted to suggest that keeping COPD patients at work would have a positive impact on their physical health. Because of persistent symptoms of breathlessness, persons with COPD tend to adopt a sedentary life style, which reduces their physical condition in a downward spiral, referred to as the “COPD vicious cycle”.8,49 Paid work may help persons to keep up with daily routines and require them to be at least somewhat physically active, thereby delaying this cycle. Thus, these results might also suggest the possibility that promoting work-related rehabilitation for those with work capacity could be beneficial for maintaining or improving quality of life among subjects with COPD. Kremer et al50 pointed out in their study that, in order to influence participation in paid work in this population, more attention should be paid to work place adjustments. Therefore, interventions for COPD patients who are still working should be designed and evaluated in future research.

Partnership

Living with a partner was related to higher MCS scores in the present study, in accordance with studies showing that marital satisfaction is a strong predictor of life satisfaction and well-being.51 In PR, patients with poor attendance have been found to have less social support.52 On the other hand, a study by Bratås et al53 yielded interesting insights regarding the role of next of kin and PR, showing that patients living alone are more likely to achieve or improve their HRQoL 6 months after rehabilitation compared to patients living with someone. Although living alone might require greater self-care and self-responsibility, the above study recommends involving a spouse or partner in PR in order to improve the maintenance of its positive effects.53

Sex differences

Women had lower scores than men on several HRQoL scales and on the MCS. Other studies also report lower MCS scores in women than men with COPD and severe emphysema,54–57 and a Dutch population-based study also demonstrated lower PCS scores among women compared to men.58 These findings underscore the necessity for more studies of sex differences in order to tailor the provision of health care services to the potentially differing needs of men and women and thereby achieve comparable health outcomes.

Representativity of the sample

The selection of patients in the present sample is not random, but does represent many rehabilitation centers in Southern Norway. The inclusion rate is high (76%), and comparison of study participants and non-participants indicates no differences in relation to age or the proportions of men and women. In Norway, patients are generally referred to PR by their general practitioner or by a lung specialist, and the public health system covers the expenses. However, no standard written criteria for referral exists. Guidelines from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) emphasize referral at an early stage of the disease to promote earlier use of preventive strategies.8 Criteria based on lung function parameters alone is not recommended in patient selection, since forced expiratory volume in 1 second (FEV1) is a relatively poor correlate of symptoms such as breathlessness and the impact of COPD on daily life.59 Selection could also be based on functional limitations due to respiratory symptoms, potential for improvement, and motivation to participate actively.60 Although more information is needed on criteria for patient selection for PR, all COPD patients appear to benefit.8 From clinical experience, we know that the distribution of disease severity and other relevant characteristics shows wide variations in patients attending such courses. Our sample probably reflects the heterogeneity in a natural setting of patients attending PR, and should therefore be representative, allowing generalizations about Norwegian patients enrolled in PR. As a result, this study provides important insights into some of the factors that are associated with the physical and mental components of HRQoL in this population.

Study limitations

This study has some limitations. First is the lack of available data regarding disease severity, performance-based physical activity, and other clinical variables (eg, body mass index, smoking history, and comorbid conditions), as these factors may influence the relationships observed in this study. However, previous research has demonstrated low61 to moderate5 correlation between HRQoL, as measured with the SF-36, and disease severity among COPD patients. Another study limitation is that the cross-sectional design prevents interpretations of causality, and additional longitudinal studies are warranted to determine the nature of relationships between general self-efficacy and HRQoL over time in this population. Since our study relied on self-reported data, another limitation is that the participants’ answers may have been influenced by their wish to either exaggerate or minimize the effect of their disease on issues such as levels of physical activity. This possible threat to validity should be common for all participants, but the study would have been strengthened by the inclusion of objective measures.

Conclusion

The present study suggests that physical activity, general self-efficacy, participation in paid work, and partnership might be important factors for improving the HRQoL of persons with COPD and should be taken into consideration in pulmonary rehabilitation. These factors might also play a role in reducing the attrition of benefits commonly observed after patients leave PR,19,62 but further research is needed to clarify such relationships. Nonetheless, to maintain patients’ HRQoL, individualized needs assessments are recommended, with particular emphasis on their self-care abilities and factors such as physical activity, paid work, social relationships, and self-efficacy.63