Literature DB >> 2494378

Lysolecithin concentration in pancreatic tissue during therapy with phospholipase A2-inhibitors in acute necrotizing pancreatitis.

M Kahle1, H König, R D Filler.   

Abstract

Four hours after hemorrhagic necrotizing pancreatitis was induced in experimental animals the concentration of lysolecithin in pancreatic tissue rose (p = 0.0025). Parenteral administration of unspecific inhibitors of phospholipase A2, such as chlorpromazine, gabexat mesilat and CaNa2 EDTA, can neither inhibit elevation of the enzyme nor influence the course of the disease.

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Year:  1989        PMID： 2494378     DOI： 10.1007/bf01711348

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  6 in total

1.  Phosphorus assay in column chromatography.

Authors:  G R BARTLETT
Journal:  J Biol Chem       Date:  1959-03       Impact factor: 5.157

2.  Local anesthetic inhibition of pancreatic phospholipase A2 action on lecithin monolayers.

Authors:  H S Hendrickson; M C van Dam-Mieras
Journal:  J Lipid Res       Date:  1976-07       Impact factor: 5.922

3.  Effects of local anaesthetics on prostaglandin biosynthesis in vitro.

Authors:  H Kunze; E Bohn; W Vogt
Journal:  Biochim Biophys Acta       Date:  1974-09-19

4.  On the etiology and pathophysiology of acute pancreatitis, with special reference to participation of phospholipase A.

Authors:  M Hatao
Journal:  Nihon Geka Hokan       Date:  1969-01-01

Review 5.  The role of phospholipase A in acute pancreatitis.

Authors:  T J Nevalainen
Journal:  Scand J Gastroenterol       Date:  1980       Impact factor: 2.423

6.  Investigations into various pancreatic enzymes.

Authors:  P Stömmer
Journal:  Exp Pathol       Date:  1982
  6 in total
  2 in total

1.  The role of phospholipase A2 in pancreatic acinar cell injury.

Authors:  A J Hietaranta; Z G Lászik; H J Aho; P T Kortesuo; T J Nevalainen
Journal:  Int J Pancreatol       Date:  1991-02

2.  Increased activity of group II phospholipase A2 in plasma in rat sodium deoxycholate induced acute pancreatitis.

Authors:  S Furue; Y Hori; K Kuwabara; J Ikeuchi; H Onoyama; M Yamamoto; K Tanaka
Journal:  Gut       Date:  1997-12       Impact factor: 23.059
  2 in total

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