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Literature DB >> 2494295

Human monocytes can produce tissue-type plasminogen activator.

P H Hart¹, G F Vitti, D R Burgess, D K Singleton, J A Hamilton.

Abstract

Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2494295 PMCID： PMC2189243 DOI： 10.1084/jem.169.4.1509

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

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Authors: O Saksela
Journal: Biochim Biophys Acta Date: 1985-11-12

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Authors: O Saksela; T Hovi; A Vaheri
Journal: J Cell Physiol Date: 1985-01 Impact factor: 6.384

Review 3. The pathogenesis of atherosclerosis--an update.

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Journal: N Engl J Med Date: 1986-02-20 Impact factor: 91.245

4. Increased release of plasminogen activator inhibitor type 2 accompanies the human mononuclear cell tissue factor response to lipopolysaccharide.

Authors: B S Schwartz; M C Monroe; E G Levin
Journal: Blood Date: 1988-03 Impact factor: 22.113

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Authors: G Vitti; J A Hamilton
Journal: Arthritis Rheum Date: 1988-08

6. Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity.

Authors: P H Hart; G A Whitty; D S Piccoli; J A Hamilton
Journal: J Immunol Date: 1988-09-01 Impact factor: 5.422

7. Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.

Authors: R Fisher; E K Waller; G Grossi; D Thompson; R Tizard; W D Schleuning
Journal: J Biol Chem Date: 1985-09-15 Impact factor: 5.157

8. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation.

Authors: H A Chapman; O L Stone; Z Vavrin
Journal: J Clin Invest Date: 1984-03 Impact factor: 14.808

9. Novel properties of human monocyte plasminogen activator.

Authors: R W Stephens; J P Golder
Journal: Eur J Biochem Date: 1984-03-01

10. Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

Authors: J D Vassalli; J M Dayer; A Wohlwend; D Belin
Journal: J Exp Med Date: 1984-06-01 Impact factor: 14.307

11 in total

1. Bleeding diathesis coincident with chronic myelomonocytic leukaemia.

Authors: S E Heard; P Revell; L J Holland; A D Hurdle; G F Savidge
Journal: J Clin Pathol Date: 1991-11 Impact factor: 3.411

2. Regulation by interleukin-3 of human monocyte pro-inflammatory mediators. Similarities with granulocyte-macrophage colony-stimulating factor.

Authors: P H Hart; G A Whitty; D R Burgess; J A Hamilton
Journal: Immunology Date: 1990-09 Impact factor: 7.397

3. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus.

Authors: S E Tsirka; A D Rogove; T H Bugge; J L Degen; S Strickland
Journal: J Neurosci Date: 1997-01-15 Impact factor: 6.167

4. Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target.

Authors: Luisana Avilán; Melisa Gualdrón-López; Wilfredo Quiñones; Limari González-González; Véronique Hannaert; Paul A M Michels; Juan-Luis Concepción
Journal: Enzyme Res Date: 2011-04-07

5. Regulation of plasminogen receptor expression on human monocytes and monocytoid cell lines.

Authors: J Felez; L A Miles; J Plescia; E F Plow
Journal: J Cell Biol Date: 1990-10 Impact factor: 10.539

6. Interleukin-4 suppresses granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor levels in stimulated human monocytes.

Authors: J A Hamilton; G A Whitty; A K Royston; J Cebon; J E Layton
Journal: Immunology Date: 1992-08 Impact factor: 7.397