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Literature DB >> 24942399

Warfarin pharmacogenetics: to genotype or not to genotype, that is the question.

Abstract

Genotype is well recognized to influence the dose of warfarin necessary for therapeutic anticoagulation. Recent randomized controlled trials evaluating the clinical utility of genotype-guided warfarin dosing have produced varying results. We review the design and results of the recent clinical trials, assess the impact of their findings on warfarin dosing, and examine unanswered questions related to clinical implementation of warfarin pharmacogenetics.

Entities: Chemical

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Year: 2014 PMID： 24942399 DOI： 10.1038/clpt.2014.78

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

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Cited

12 in total

1. Limited clinical utility of genotype-guided warfarin initiation dosing algorithms versus standard therapy: a meta-analysis and trial sequential analysis of 11 randomized controlled trials.

Authors: H L Tang; W L Shi; X G Li; T Zhang; S D Zhai; H G Xie
Journal: Pharmacogenomics J Date: 2015-04-14 Impact factor: 3.550

Review 2. The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics.

Authors: Ute I Schwarz; Markus Gulilat; Richard B Kim
Journal: Cold Spring Harb Perspect Med Date: 2019-02-01 Impact factor: 6.915

3. The Application of Genomics in Diabetes: Barriers to Discovery and Implementation.

Authors: James S Floyd; Bruce M Psaty
Journal: Diabetes Care Date: 2016-11 Impact factor: 19.112

Review 4. Pharmacogenomics in the clinic.

Authors: Mary V Relling; William E Evans
Journal: Nature Date: 2015-10-15 Impact factor: 49.962

Review 5. Precision dosing of warfarin: open questions and strategies.

Authors: Xi Li; Dan Li; Ji-Chu Wu; Zhao-Qian Liu; Hong-Hao Zhou; Ji-Ye Yin
Journal: Pharmacogenomics J Date: 2019-02-12 Impact factor: 3.550

6. Influence of PSRC1, CELSR2, and SORT1 Gene Polymorphisms on the Variability of Warfarin Dosage and Susceptibility to Cardiovascular Disease.

Authors: Laith N Al-Eitan; Barakat Z Elsaqa; Ayah Y Almasri; Hatem A Aman; Rame H Khasawneh; Mansour A Alghamdi
Journal: Pharmgenomics Pers Med Date: 2020-11-17

7. Validation and Application of a Simple UHPLC-MS-MS Method for the Enantiospecific Determination of Warfarin in Human Urine.

Authors: Osama Y Alshogran; Andrew J Ocque; François A Leblond; Vincent Pichette; Thomas D Nolin
Journal: J Chromatogr Sci Date: 2015-12-11 Impact factor: 1.618