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Literature DB >> 24941917

Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network.

Xianzhong Xu¹, Surya V S R K Pulavarti, Alexander Eletsky, Yuanpeng Janet Huang, Thomas B Acton, Rong Xiao, John K Everett, Gaetano T Montelione, Thomas Szyperski.

Abstract

High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. These domains were chosen as targets of a biomedical theme project pursued by the Northeast Structural Genomics Consortium. This project focuses on increasing the structural coverage of human proteins associated with cancer.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2014 PMID： 24941917 PMCID： PMC4239167 DOI： 10.1007/s10969-014-9184-z

Source DB: PubMed Journal: J Struct Funct Genomics ISSN： 1345-711X

56 in total

1. Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.

Authors: Ken-ichi Miyazono; Yuehua Zhi; Yuriko Takamura; Koji Nagata; Kaoru Saigo; Tetsuya Kojima; Masaru Tanokura
Journal: EMBO J Date: 2010-04-13 Impact factor: 11.598

2. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.

Authors: Hans Wienk; Ivonne Lammers; Anna Hotze; Jin Wu; Rainer W Wechselberger; Ray Owens; David K Stammers; David Stuart; Robert Kaptein; Gert E Folkers
Journal: Biochemistry Date: 2009-06-02 Impact factor: 3.162

3. Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer.

Authors: H Chang; N Mohabir; S Done; P A Hamel
Journal: J Clin Pathol Date: 2009-10 Impact factor: 3.411

4. The Pfam protein families database.

Authors: Robert D Finn; Jaina Mistry; John Tate; Penny Coggill; Andreas Heger; Joanne E Pollington; O Luke Gavin; Prasad Gunasekaran; Goran Ceric; Kristoffer Forslund; Liisa Holm; Erik L L Sonnhammer; Sean R Eddy; Alex Bateman
Journal: Nucleic Acids Res Date: 2009-11-17 Impact factor: 16.971

5. Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions.

Authors: Marc Tänzer; Benjamin Balluff; Jürgen Distler; Kari Hale; Andreas Leodolter; Christoph Röcken; Bela Molnar; Roland Schmid; Catherine Lofton-Day; Tibor Schuster; Matthias P A Ebert
Journal: PLoS One Date: 2010-02-04 Impact factor: 3.240

6. Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.

Authors: Louise E Bird; Jingshan Ren; Joanne E Nettleship; Gert E Folkers; Raymond J Owens; David K Stammers
Journal: BMC Struct Biol Date: 2010-05-28

7. ALX4 dysfunction disrupts craniofacial and epidermal development.

Authors: Hulya Kayserili; Elif Uz; Carien Niessen; Ibrahim Vargel; Yasemin Alanay; Gokhan Tuncbilek; Gokhan Yigit; Oya Uyguner; Sukru Candan; Hamza Okur; Serkan Kaygin; Sevim Balci; Emin Mavili; Mehmet Alikasifoglu; Ingo Haase; Bernd Wollnik; Nurten Ayse Akarsu
Journal: Hum Mol Genet Date: 2009-08-19 Impact factor: 6.150

1. A 20 bp Duplication in Exon 2 of the Aristaless-Like Homeobox 4 Gene (ALX4) Is the Candidate Causative Mutation for Tibial Hemimelia Syndrome in Galloway Cattle.

Authors: Bertram Brenig; Ekkehard Schütz; Michael Hardt; Petra Scheuermann; Markus Freick
Journal: PLoS One Date: 2015-06-15 Impact factor: 3.240

1 in total