Hepatotoxicity, leucopenia and neutropenia associated with olanzapine therapy.

Hepatotoxicity, leukopenia and neutropenia are rarely associated with atypical antipsychotic drug therapy. The authors describe a case of a schizophrenic patient, who was treated twice with olanzapine, and who developed an increase of hepatic enzymes, jaundice, reduced WBC, neutropenia, and a high temperature. The patient was diagnosed as suffering from hepatocellular hepatitis, neutropenia and leucopenia. Neuroleptic treatment was discontinued immediately and the patient exhibited consequential clinical improvement. A review of the literature is included.